Outcome = CES-D (absolute score) | Model 3A | Model 3B* | Model 3C* | Model 3D* | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
B | 95% CI | p | B | 95% CI | p | B | 95% CI | p | B | 95% CI | p | |
Group, IFX | − 0.39 | − 2.01 to 1.23 | 0.63 | 0.87 | − 1.97 to 3.71 | 0.55 | − 0.80 | − 2.85 to 1.25 | 0.44 | 1.16 | − 1.87 to 4.19 | 0.45 |
Baseline CES-D, score | 0.78 | 0.46 to 1.11 | < 0.01 | 0.74 | 0.53 to 0.95 | < 0.01 | 0.77 | 0.43 to 1.11 | < 0.01 | 0.75 | 0.53 to 0.96 | < 0.01 |
Time, 6 weeks | − 2.30 | − 8.09 to 3.49 | 0.44 | − 1.62 | − 6.31 to 3.07 | 0.50 | − 2.31 | − 8.14 to 3.53 | 0.44 | − 1.59 | − 6.22 to 3.04 | 0.50 |
Time, 12 weeks | − 0.42 | − 5.63 to 4.78 | 0.87 | 0.43 | − 4.01 to 4.87 | 0.85 | − 0.58 | − 5.88 to 4.72 | 0.83 | 0.55 | − 3.87 to 4.96 | 0.81 |
Time, 24 weeks | 0.62 | − 4.69 to 5.92 | 0.82 | 0.92 | − 3.85 to 5.70 | 0.71 | 0.42 | − 4.92 to 5.75 | 0.88 | 1.05 | − 3.75 to 5.86 | 0.67 |
Group*time (6 weeks) | − 2.94 | − 9.23 to 3.35 | 0.36 | − 0.84 | − 6.15 to 4.46 | 0.75 | − 2.24 | − 8.92 to 4.44 | 0.51 | − 1.20 | − 6.53 to 4.14 | 0.66 |
Group*time (12 weeks) | − 4.22 | − 10.32 to 1.87 | 0.17 | − 2.19 | − 7.50 to 3.12 | 0.42 | − 3.27 | − 9.69 to 3.16 | 0.32 | − 2.69 | − 7.84 to 2.47 | 0.31 |
Group*time (24 weeks) | − 6.63 | − 13.35 to 0.09 | 0.05 | − 3.89 | − 10.04 to 2.27 | 0.22 | − 5.71 | − 12.53 to 1.12 | 0.10 | − 4.34 | − 10.38 to 1.69 | 0.16 |
BASFI | − | − | − | 1.56 | 0.81 to 2.31 | < 0.01 | − | − | − | 1.61 | 0.80 to 2.42 | < 0.01 |
CRP, mg/L | − | − | − | − | − | − | 0.04 | − 0.02 to 0.10 | 0.24 | − 0.02 | − 0.08 to 0.04 | 0.46 |
Outcome = CES-D (increased vs. normal)† | Model 4A | Model 4B* | Model 4C* | Model 4D* | ||||||||
OR | 95% CI | p | OR | 95% CI | p | OR | 95% CI | p | OR | 95% CI | p | |
Group, IFX | 1.17 | 0.34 to 4.03 | 0.80 | 1.59 | 0.42 to 6.06 | 0.50 | 1.02 | 0.26 to 3.96 | 0.98 | 1.60 | 0.37 to 6.97 | 0.53 |
Baseline CES-D, increased† | 8.18 | 2.06 to 32.44 | < 0.01 | 12.57 | 2.11 to 74.95 | < 0.01 | 7.22 | 1.88 to 27.83 | < 0.01 | 12.68 | 1.94 to 82.94 | < 0.01 |
Time, 6 weeks | 1.09 | 0.04 to 27.97 | 0.96 | 1.43 | 0.07 to 29.08 | 0.82 | 1.11 | 0.04 to 31.26 | 0.95 | 1.43 | 0.07 to 28.96 | 0.82 |
Time, 12 weeks | 1.34 | 0.13 to 14.07 | 0.81 | 1.76 | 0.25 to 12.46 | 0.57 | 1.29 | 0.11 to 15.06 | 0.84 | 1.77 | 0.25 to 12.58 | 0.57 |
Time, 24 weeks | 4.18 | 0.26 to 67.75 | 0.31 | 4.73 | 0.38 to 58.18 | 0.23 | 3.95 | 0.24 to 65.05 | 0.34 | 4.74 | 0.37 to 60.52 | 0.23 |
Group*time (6 weeks) | 0.17 | 0.00 to 6.66 | 0.35 | 0.21 | 0.01 to 7.10 | 0.38 | 0.23 | 0.01 to 10.97 | 0.46 | 0.21 | 0.01 to 7.91 | 0.40 |
Group*time (12 weeks) | 0.16 | 0.01 to 2.89 | 0.22 | 0.21 | 0.01 to 3.18 | 0.26 | 0.25 | 0.01 to 5.92 | 0.39 | 0.21 | 0.01 to 4.14 | 0.30 |
Group*time (24 weeks) | 0.02 | 0.00 to 0.72 | 0.03 | 0.02 | 0.00 to 0.79 | 0.04 | 0.03 | 0.00 to 1.30 | 0.07 | 0.02 | 0.00 to 1.13 | 0.06 |
BASFI | − | − | − | 1.49 | 1.07 to 2.09 | 0.02 | − | − | − | 1.50 | 1.02 to 2.21 | 0.04 |
CRP, mg/L | − | − | − | – | − | − | 1.02 | 0.99 to 1.05 | 0.21 | 1.00 | 0.97 to 1.03 | 0.96 |