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Table 1 Relevant studies concerning relationships between GDF5 rs143383 polymorphisms and knee osteoarthritis

From: Association between growth differentiation factor 5 rs143383 genetic polymorphism and the risk of knee osteoarthritis among Caucasian but not Asian: a meta-analysis

Author Year Country Ethnicity Type of disease Study design Sample size of case/control Genotyping methods HWE among controls NOS
Elazeem et al. [16] 2017 Egypt Caucasian KOA Case-control 50/50 Taqman 0.58 8
Ozcan et al. [17] 2016 Turkey Caucasian KOA Case-control 94/279 PCR-RFLP 0.06 8
Mishra et al. [15] 2013 India Asian KOA Case-control 300/300 PCR-RFLP 0.97 8
Tawonsawatruk et al. [19] 2011 Thailand Asian KOA Case-control 90/103 PCR-RFLP 0.63 8
Cao et al. [20] 2010 Korea Caucasian KOA Case-control 276/298 PCR-RFLP 0.34 8
Valdes et al.—Nottingham [21] 2009 UK Caucasian KOA Case-control 735/654 Allele-specific PCR 0.99 8
Valdes et al.—Chingford [25] 2009 UK Caucasian KOA Case-control 259/509 Allele-specific PCR 0.90 8
Tsezou et al. [22] 2007 Greece Caucasian KOA Case-control 251/268 Direct sequence 0.66 8
Miyamoto et al.—Japan [18] 2007 Japan Asian KOA Case-control 718/861 Taqman 0.96 8
Miyamoto et al.—China [18] 2007 China Asian KOA Case-control 313/485 Taqman 0.28 8
Southam et al.—UK [23] 2007 UK Caucasian KOA Case-control 509/822 PCR-RFLP 0.26 8
Southam et al.—Spain [23] 2007 Spain Caucasian KOA Case-control 274/1196 Taqman 0.54 8
Shin et al. [24] 2012 Korea Asian KOA Case-control 725/1737 High-resolution melting analysis 0.17 8
Yao et al. [28] 2008 China Asian KOA Case-control 313/485 PCR-RFLP 0.33 8
Vaes et al. [26] 2009 Netherland Caucasian KOA Case-control 667/2097 Taqman 0.72 8
Zhang et al. [5] 2019 China Asian KOA Case-control 288/397 Taqman 0.56 8
García-Alvarado et al. [27] 2018 Mexico Caucasian KOA Case-control 145/145 RT-PCR 0.89 8
Valdes et al.—GOAL [25] 2011 UK Caucasian KOA Case-control 867/758 Allele-specific PCR 0.83 8
Valdes et al.—Hertfordshire [25] 2011 UK Caucasian KOA Case-control 1141/536 Allele-specific PCR 0.22 8
Chapman et al. [11] 2008 Netherland Caucasian KOA Case-control 142/724 Mass spectrometry 0.55 8