Association between growth differentiation factor 5 rs143383 genetic polymorphism and the risk of knee osteoarthritis among Caucasian but not Asian: a meta-analysis

Peng, Lei; Jin, Song; Lu, Jiping; Ouyang, Chao; Guo, Jiang; Xie, Zhongyu; Shen, Huiyong; Wang, Peng

doi:10.1186/s13075-020-02306-9

Table 1 Relevant studies concerning relationships between GDF5 rs143383 polymorphisms and knee osteoarthritis

From: Association between growth differentiation factor 5 rs143383 genetic polymorphism and the risk of knee osteoarthritis among Caucasian but not Asian: a meta-analysis

Author	Year	Country	Ethnicity	Type of disease	Study design	Sample size of case/control	Genotyping methods	HWE among controls	NOS
Elazeem et al. [16]	2017	Egypt	Caucasian	KOA	Case-control	50/50	Taqman	0.58	8
Ozcan et al. [17]	2016	Turkey	Caucasian	KOA	Case-control	94/279	PCR-RFLP	0.06	8
Mishra et al. [15]	2013	India	Asian	KOA	Case-control	300/300	PCR-RFLP	0.97	8
Tawonsawatruk et al. [19]	2011	Thailand	Asian	KOA	Case-control	90/103	PCR-RFLP	0.63	8
Cao et al. [20]	2010	Korea	Caucasian	KOA	Case-control	276/298	PCR-RFLP	0.34	8
Valdes et al.—Nottingham [21]	2009	UK	Caucasian	KOA	Case-control	735/654	Allele-specific PCR	0.99	8
Valdes et al.—Chingford [25]	2009	UK	Caucasian	KOA	Case-control	259/509	Allele-specific PCR	0.90	8
Tsezou et al. [22]	2007	Greece	Caucasian	KOA	Case-control	251/268	Direct sequence	0.66	8
Miyamoto et al.—Japan [18]	2007	Japan	Asian	KOA	Case-control	718/861	Taqman	0.96	8
Miyamoto et al.—China [18]	2007	China	Asian	KOA	Case-control	313/485	Taqman	0.28	8
Southam et al.—UK [23]	2007	UK	Caucasian	KOA	Case-control	509/822	PCR-RFLP	0.26	8
Southam et al.—Spain [23]	2007	Spain	Caucasian	KOA	Case-control	274/1196	Taqman	0.54	8
Shin et al. [24]	2012	Korea	Asian	KOA	Case-control	725/1737	High-resolution melting analysis	0.17	8
Yao et al. [28]	2008	China	Asian	KOA	Case-control	313/485	PCR-RFLP	0.33	8
Vaes et al. [26]	2009	Netherland	Caucasian	KOA	Case-control	667/2097	Taqman	0.72	8
Zhang et al. [5]	2019	China	Asian	KOA	Case-control	288/397	Taqman	0.56	8
García-Alvarado et al. [27]	2018	Mexico	Caucasian	KOA	Case-control	145/145	RT-PCR	0.89	8
Valdes et al.—GOAL [25]	2011	UK	Caucasian	KOA	Case-control	867/758	Allele-specific PCR	0.83	8
Valdes et al.—Hertfordshire [25]	2011	UK	Caucasian	KOA	Case-control	1141/536	Allele-specific PCR	0.22	8
Chapman et al. [11]	2008	Netherland	Caucasian	KOA	Case-control	142/724	Mass spectrometry	0.55	8

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