Association between growth differentiation factor 5 rs143383 genetic polymorphism and the risk of knee osteoarthritis among Caucasian but not Asian: a meta-analysis

Table 2 Meta-analysis for GDF5 rs143383 polymorphisms and knee osteoarthritis risk

Variables	N	C vs T		CC+CT vs TT		CC vs CT+TT		CC vs TT		CT vs CC+TT
		OR (95% CI)	P_h	OR (95% CI)	P_h	OR (95% CI)	P_h	OR (95% CI)	P_h	OR (95% CI)	P_h
Total	20	0.836	1 × 10⁻⁴	0.80	1 × 10⁻⁴	0.79	0.001	0.88	0.002	0.88	0.002
		(0.76–0.91)		(0.72–0.90)		(0.68–0.92)		(0.80–0.97)		(0.80–0.96)
Ethnicity
Asian	8	0.84	1 × 10⁻⁴	0.80	1 × 10⁻⁴	0.76	0.002	0.85	0.011	0.85	0.011
		(0.67–1.02)		(0.63–1.00)		(0.50–1.12)		(0.72–1.00)		(0.72–1.00)
Caucasian	12	0.84	0.12	0.81	1 × 10⁻⁴	0.81	0.92	0.90	0.013	0.89	0.016
		(0.79–0.91)		(0.71–0.92)		(0.72–0.90)		(0.80–1.02)		(0.79–1.02)

N number of studies
P_h value of Q-test for heterogeneity test. Random-effects model was used when p value for heterogeneity test < 0.05; otherwise, fix-effects model was used

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