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Table 2 Variables that have an influence on lipid profile of patients with early arthritis

From: Effects of disease activity on lipoprotein levels in patients with early arthritis: can oxidized LDL cholesterol explain the lipid paradox theory?

  Total cholesterol (mg/dl) HDL cholesterol (mg/dl) LDL cholesterol (mg/dl) oxLDL (sqrt U/ml)
β coeff. ± s.e. p β coeff. ± s.e. p β coeff. ± s.e. p β coeff. ± s.e. p
Gender
 Male Ref. Ref. n.i. Ref.
 Female 10.5 ± 3.4 0.002 12.4 ± 1.9 < 0.001    −1.03 ± 0.48 0.031
Age
  < 45 years Ref. Ref. Ref. n.i.
 45–65 years 23.1 ± 3.3 < 0.001 1.9 ± 1.9 0.319 16.4 ± 3.3 < 0.001
  > 65 years 23.9 ± 3.7 < 0.001 5.6 ± 2.1 0.008 12.3 ± 3.7 0.001
BMI 0.68 ± 0.29 0.019 −0.62 ± 0.16 < 0.001 0.71 ± 0.29 0.016 n.i.
DA
 Remission Ref. Ref. Ref. Ref.
 Low 2.19 ± 1.74 0.582 −0.79 ± 1.04 0.442 1.96 ± 2.13 0.359 0.28 ± 0.48 0.564
 Moderate −3.04 ± 1.90 0.110 −3.30 ± 1.14 0.004 1.35 ± 2.30 0.556 0.43 ± 0.48 0.367
 High −14.95 ± 2.53 < 0.001 −8.89 ± 1.56 < 0.001 −6.39 ± 2.92 0.029 1.88 ± 0.66 0.004
Statins −27.4 ± 3.05 < 0.001 n.i. − 28.7 ± 3.2 < 0.001 n.i.
Smoking n.i. n.i. 7.0 ± 4.5 0.118 n.i.
MTX (mg/wk) n.i. 2.06 ± 0.94 0.029 n.i. n.i.
Leflunomide (mg/d) 6.4 ± 2.2 0.003 2.35 ± 1.27 0.064 4.79 ± 2.57 0.062 n.i.
Abatacept (Y/N) 36.94 ± 16.01 0.021 40.54 ± 9.57 < 0.001 n.i. n.i.
TNF i (Y/N) n.i. n.i. n.i. 1.597 ± 1.003 0.111
LDL (mg/dl) n.i. n.i. n.i. 0.015 ± 0.005 0.005
Frozen storage (months) n.i. n.i. n.i. −0.003 ± 0.001 < 0.001
  1. Abbreviations: β coeff. beta coefficient, BMI body mass index, DA Disease activity assessed with, HUPI Hospital Universitario La Princesa Index, HDL high-density lipoproteins, LDL low-density lipoproteins, MTX methotrexate, N no, n.i. not included (not relevant to the model), oxLDL oxidized LDL, p p value, Ref. reference variable, s.e. standard error, sqrt square root, n.i. not included (not relevant to the model), TNFi TNF inhibitors, wk week, Y yes. Due to multiple comparisons, statistical significance was considered if p < 0.01. In bold, significant p values