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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Interleukin (IL)-25 suppresses IL-22-induced osteoclastogenesis in rheumatoid arthritis via STAT3 and p38 MAPK/IκBα pathway

Fig. 3

Intracellular signaling pathways involving in the regulation of IL-25 in IL-22-induced RANKL expression in RA synovial fibroblasts. a Immunoblotting of p-stat3, stat3, p-P38, P38, p-IκB-α, IκB-α, and beta-actin in the RA synovial fibroblasts pre-treated with IL-25 (10, 50, 100 ng/ml) and then cultured under IL-22 for 1 h. b Data were normalized to beta-actin and reported in relative expression units. Bars show the mean ± SEM of 3 independent experiments. *P < 0.05, **P < 0.01, and ***P < 0.001

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