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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: MicroRNA-15b shuttled by bone marrow mesenchymal stem cell-derived extracellular vesicles binds to WWP1 and promotes osteogenic differentiation

Fig. 1

WWP1 is targeted and negatively regulated by miR-15b. a The binding of miR-15b to WWP1 3′-UTR predicted by Starbase software. b The targeting relationship between miR-15b and WWP1 evaluated by dual-luciferase reporter assay. c miR-15b expression and WWP1 mRNA expression in BMSCs after transfection with mimic-NC or miR-15b mimic detected by RT-qPCR normalized to U6 and GAPDH. d WWP1 protein expression in BMSCs after transfection with mimic-NC or miR-15b mimic detected by Western blot analysis normalized to GAPDH. The measurement data were shown as mean ± standard deviation and compared by independent sample t test. The cell experiment was repeated three times. *p < 0.05 vs. transfection with mimic-NC

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