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Fig. 7 | Arthritis Research & Therapy

Fig. 7

From: MicroRNA-15b shuttled by bone marrow mesenchymal stem cell-derived extracellular vesicles binds to WWP1 and promotes osteogenic differentiation

Fig. 7

Bone loss was suppressed by BMSC-derived EVs loaded with miR-15b in OVX rats. Sham-operated rats were used as controls, while OVX rats were treated with or without EVs, EV-inhibitor NC, or EV-miR-15b inhibitor. a The morphology of rat tibia observed by HE staining (× 200). b Micro-CT analysis of tibia tissues of rats. c BV/TV of rats. d BMD of rats. e Tb.N of rats. f Tb.Th of rats. g Conn.D of rats. *p < 0.05 vs. sham-operated rats. #p < 0.05 vs. OVX rats. &p < 0.05 vs. OVX rats treated with EV-inhibitor NC. The measurement data were shown as mean ± standard deviation and compared by one-way ANOVA, followed by Tukey’s post hoc test. n = 8

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