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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Long-term changes in renal function after treatment initiation and the importance of early diagnosis in maintaining renal function among IgG4-related tubulointerstitial nephritis patients in Japan

Fig. 3

Least squares means (95% CI) of eGFR (mL/min/1.73m2) at baseline (i.e., at treatment initiation) and months after the treatment initiation according to histological stage A and stage B in patients with IgG4-related TIN (n = 24) based on linear mixed models. Significantly lower values of eGFR were observed in patients with stage B compared to patients with stage A. Those mean differences in eGFR correspond to Table 4. On the other hand, there were no significant difference in change rates of eGFR (i.e., eGFR slope) between patients with stage A and stage B (the mean difference of the monthly slope of the eGFR [95% CI] 0.0 [− 0.1 to 0.2] in model 2), meaning the mean differences of eGFR were stable during the clinical course (baseline to 60 months). Abbreviations: CI, confidence interval; eGFR, estimated glomerular filtration rate; TIN, tubulointerstitial nephritis

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