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Table 3 Mean differences (95% CI) in eGFR at the baseline and each time point according to whether or not patients had been diagnosed at the initial examination (n = 24), obtained by linear mixed models

From: Long-term changes in renal function after treatment initiation and the importance of early diagnosis in maintaining renal function among IgG4-related tubulointerstitial nephritis patients in Japan

Months after treatment

Baselinec

1

2

6

12

24

36

60

Mean differences in eGFR (ml/min/1.73 m2) in model 1a

 Cases not diagnosed by renal biopsy at the initial examinationd

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

 Cases diagnosed by renal biopsy at the initial examination

9.7 (− 1.5, 20.9)

9.7 (− 1.2, 20.6)

9.7 (− 1.5, 20.9)

9.7 (− 0.9, 20.4)

9.7 (− 0.2, 19.6)

9.7 (0.5, 18.9)

9.7 (1.1, 18.3)

9.7 (1.6, 17.8)

Mean differences in eGFR (ml/min/1.73 m2) in model 2b

 Cases not diagnosed by renal biopsy at the initial examinationd

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

 Cases diagnosed by renal biopsy at the initial examination

6.1 (0.7, 11.5)

6.1 (0.7, 11.4)

6.1 (0.8, 11.3)

6.0 (1, 11.0)

6.0 (1.3, 10.6)

5.8 (1.4, 10.3)

5.7 (0.9, 10.4)

5.4 (− 1.2, 12.0)

  1. Abbreviations: CI confidence interval, eGFR estimated glomerular filtration rate, Ref. reference group, CKD chronic kidney disease
  2. aModel 1 was adjusted for age at the renal biopsy, sex, and hemodialysis
  3. bModel 2 was the model 1 with additional adjustment for CKD stage and difference in the number of days between the renal biopsy and the initiation of glucocorticoid treatment
  4. cThe baseline was the time at treatment initiation
  5. dThis was because there were patients who had renal biopsy before IgG4-related TIN became a recognized entity. Patients in this group were not diagnosed with IgG4-related TIN during the observation period of the present study
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Arthritis Research & Therapy

ISSN: 1478-6362

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