Table 3 Associations between MPA exposure and clinical characteristics

Disease subtype (lcSSc vs dcSSc)

119 (90–132) vs 98 (85–150), p = 0.929

72 (48–85) vs 75 (59–116), p = 0.383

N/A

73 (43–101) vs 65 (56–121)

118 (27–139) vs 125 (83–139)

Sex (male vs female)

74 (36–103) vs 121 (94–141), p = 0.015

58 (31–81) vs 72 (60–103), p = 0.262

N/A

58 (43–73) vs 71 (47–121)

55 (27–83) vs 123 (68–139)

Topoisomerase (positive vs rest)

87 (67–108) vs 123 (97–146), p = 0.008

58 (31–71) vs 78 (63–103), p = 0.039

25 (25) vs 56 (41–75)

61 (43–72) vs 77 (47–121)

72 (27–118) vs 123 (68–139)

F-calprotectin (pathological vs normal)

99 (74–119) vs 127 (100–144), p = 0.025

57 (42–71) vs 83 (69–116), p = 0.001

41 (25–63) vs 62 (48–75)

58 (43–101) vs 82 (61–121)

72 (27–118) vs 123 (68–139)

Dysbiosis index ≥ 3

114 (74–139) vs 120 (86–141), p = 0.756

71 (57–119) vs 81 (61–94), p = 0.943

44 (25–63) vs 75

65 (43–104) vs 81 (56–121)

125 (68–139) vs 83 (27–120)

MUST pathological

108 (87–134) vs 114 (87–141), p = 0.817

72 (58–124) vs 72 (58–102), p = 0.857

N/A

N/A

N/A

PPI (user vs non-user)

108 (84–137) vs 121 (108–143), p = 0.341

67 (56–86) vs 92 (72–125), p = 0.060

N/A

66 (43–120) vs 76 (31–103)

100 (27–139) vs 130 (120–139)

CCB (user vs non-user)

109 (87–141) vs 122 (87–135), p = 0.765

73 (60–102) vs 63 (49–115) p = 0.591

48 (25–75) vs 52 (41–63)

72 (43–121) vs 59 (47–83)

100 (27–139) vs 132 (125–139)

NSAID (user vs non-user)

120 vs 108 (84–139) p = 0.524

73 vs 72 (58–101) p = 0.909

N/A

N/A

N/A

 Body weight

r_s = − 0.58, p < 0.001

r_s = − 0.38, p = 0.029

r_s = − 0.50

r_s = − 0.55

r_s = − 0.48

 Age

r_s = 0.33, p = 0.053

r_s = 0.10, p = 0.574

r_s = 0.90

r_s = 0.32

r_s = − 0.24

 Disease duration

r_s = − 0.10, p = 0.566

r_s = − 0.244, p = 0.164

r_s = − 0.30

r_s = − 0.21

r_s = 0.29

 Years on MMF

r_s = 0.29, p = 0.102

r_s = 0.52, p = 0.002

r_s = 0.50

r_s = 0.18

r_s = 0.53

 Disease activity

r_s = − 0.06, p = 0.728

r_s = − 0.17, p = 0.349

r_s = − 0.50

r_s = 0.08

r_s = − 0.667

 eGFR

r_s = − 0.34, p = 0.054

r_s = − 0.024, p = 0.894

rs = − 0.30

rs = − 0.21

rs = − 0.56

 Albumin

r_s = − 0.17, p = 0.351

r_s = 0.06, p = 0.762

r_s = 0.95

r_s = − 0.34

r_s = − 0.22

 PPI dose

r_s = − 0.45, p = 0.007

r_s = − 0.43, p = 0.012

r_s = − 0.71

r_s = − 0.52

r_s = − 0.31

 UCLA GIT 2.0

r_s = 0.16, p = 0.358

r_s = 0.15, p = 0.385

r_s = 0.90

r_s = 0.159

r_s = − 0.048

 F-calprotectin

r_s = − 0.36, p = 0.034

r_s = − 0.60, p = 0.010

r_s = − 0.31

r_s = − 0.53

r_s = − 0.50

 Lactobacilli

r_s = − 0.54, p = 0.004

r_s = − 0.49, p = 0.010

N/A

r_s = − 0.60

r_s = − 0.14

 MMF indication

p = 0.699

p = 0.513

N/A

N/A

N/A

 Serology

p = 0.005

p = 0.297

N/A

N/A

N/A

 MMF brand

p = 0.897

p = 0.746

N/A

p = 0.512

p = 0.547