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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Ectopic bone formation and systemic bone loss in a transmembrane TNF-driven model of human spondyloarthritis

Fig. 4

TgA86 peripheral disease progression involves features of inflammation, bone erosion, and ectopic new bone formation. a Representative H&E stained sections of hind limbs show the accumulation of cells in the joints of TgA86 mice including features of enthesitis (arrow 1), synovitis (arrow 2), bone erosion (box), and bone destruction (asterisk) highlighted in higher magnification (lower panels). b Representative TRAP-stained sections of hind limbs show the accumulation of active osteoclasts in the joints of 10- and 20-week-old TgA86 mice, while their number is reduced in the joints of 40-week-old TgA86 mice. c, d Safranin O-stained sections of hind limbs of 20-week-old (c) and 40-week-old (d) TgA86 mice show the presence of fibrocartilage and ectopic chondrocytes (black arrows)

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