Fig. 5

The cellular composition of the TgA86 axial pathology involves mesenchymal and osteoblastic lineage cells. a Vimentin, osteopontin (OPN), and periostin staining on the surface and the bone marrow cavity of the tail vertebral bodies as well as in the periphery of the intervertebral disks of 20-week-old TgA86 mice, indicate active new bone formation processes involving mesenchymal and osteoblastic lineage cells. b B220-positive cells form aggregates in the bone marrow cavity, while Gr1-positive cells accumulate at the sites of enthesis of 20-week-old TgA86 mice