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Table 2 Univariate Cox regression analysis of factors influencing risk of death in patients with ≥ 1 HAQ-DI measurement

From: Health Assessment Questionnaire-Disability Index (HAQ-DI) use in modelling disease progression in diffuse cutaneous systemic sclerosis: an analysis from the EUSTAR database

Baseline parameter HR 95% CI for HR p value
Male gender 1.15 0.57, 2.35 0.698
HAQ-DI score 3.01 1.98, 4.60 < 0.001
Age at onset of RP 1.03 1.00, 1.05 0.030
mRSS 1.02 0.99, 1.05 0.303
RNA polymerase III positive 0.04 0.00, 11.11 0.260
Anti-topoisomerase I antibody 0.92 0.45, 1.88 0.817
Immunomodulator treatment 0.86 0.45, 1.63 0.638
Corticosteroids > 10 mg/day 6.29 2.64, 14.98 < 0.001
One advanced organ involvement 3.93 1.99, 7.78 < 0.001
Two advanced organ involvement 8.43 3.40, 20.91 < 0.001
Advanced lung involvement 4.81 2.37, 9.77 < 0.001
Advanced cardiac involvement 6.24 1.47, 26.50 0.013
Advanced GI involvement 2.22 1.06, 4.64 0.035
Advanced PH involvement 6.50 2.66, 15.88 < 0.001
Advanced renal involvement 1.12 0.15, 8.13 0.914
  1. CI confidence interval, GI gastrointestinal, HAQ-DI Health Assessment Questionnaire-Disability Index, HR hazard ratio, mRSS Modified Rodnan Skin Score, PH pulmonary arterial hypertension, RP Raynaud’s phenomenon