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Table 3 ASP5094 serum concentrations by time and dosing

From: ASP5094, a humanized monoclonal antibody against integrin alpha-9, did not show efficacy in patients with rheumatoid arthritis refractory to methotrexate: results from a phase 2a, randomized, double-blind, placebo-controlled trial

 

Baseline (day 1)

Week 1 (n = 32)

Week 2 (n = 32)

Week 4

Week 8

Week 12 (n = 27)

Week 16 (n = 27)

Pre (n = 33)

Post (n = 33)

Pre (n = 31)

Post (n = 27)

Pre (n = 27)

Post (n = 27)

Mean ± SD

0 ± NA

242 ± 42.9

101 ± 17.2

64.2 ± 10.5

27.2 ± 10.2

270 ± 42.4

38.4 ± 13.8

292 ± 39.5

43.1 ± 16.7

5.55 ± 6.5

Median (range)

0 (0–0)

240 (139–345)

102 (67–149)

63.6 (43.3–85)

26.8 (10.6–51.6)

264 (198–364)

35.3 (13.3–67)

289 (227–372)

42.1 (11.6–91.6)

3.95 (0–26.6)

  1. NA not available, SD standard deviation