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Table 3 ASP5094 serum concentrations by time and dosing

From: ASP5094, a humanized monoclonal antibody against integrin alpha-9, did not show efficacy in patients with rheumatoid arthritis refractory to methotrexate: results from a phase 2a, randomized, double-blind, placebo-controlled trial

  Baseline (day 1) Week 1 (n = 32) Week 2 (n = 32) Week 4 Week 8 Week 12 (n = 27) Week 16 (n = 27)
Pre (n = 33) Post (n = 33) Pre (n = 31) Post (n = 27) Pre (n = 27) Post (n = 27)
Mean ± SD 0 ± NA 242 ± 42.9 101 ± 17.2 64.2 ± 10.5 27.2 ± 10.2 270 ± 42.4 38.4 ± 13.8 292 ± 39.5 43.1 ± 16.7 5.55 ± 6.5
Median (range) 0 (0–0) 240 (139–345) 102 (67–149) 63.6 (43.3–85) 26.8 (10.6–51.6) 264 (198–364) 35.3 (13.3–67) 289 (227–372) 42.1 (11.6–91.6) 3.95 (0–26.6)
  1. NA not available, SD standard deviation