Table 1 Characteristics of all patients classified as having nonradiographic axial spondyloarthritis at inclusion in SCQM
Parameter | A. All nr-axSpA patients | B. All nr-axSpA patients excluding patients with co-morbid FM | ||||||
|---|---|---|---|---|---|---|---|---|
N, 495 | Men, N = 231 | Women, N = 264 | p | N, 470 | Men, N = 227 | Women, N = 243 | p | |
Age, years | 495 | 36.6 (10.9) | 38.2 (10.7) | 0.09 | 470 | 36.4 (10.9) | 38.1 (10.7) | 0.09 |
Age at symptom onset, years | 481 | 28.3 (8.4) | 28.7 (9.1) | 0.65 | 456 | 28.2 (8.4) | 28.6 (9.0) | 0.65 |
Symptom duration, years | 481 | 8.3 (9.2) | 9.6 (9.8) | 0.10 | 456 | 8.2 (9.2) | 9.5 (9.8) | 0.12 |
Diagnostic delay, years | 480 | 4.7 (7.6) | 6.0 (7.8) | 0.005 | 455 | 4.7 (7.5) | 6.0 (7.8) | 0.01 |
HLA-B27 positive, % | 453 | 76.5 | 67.0 | 0.03 | 430 | 77.0 | 68.2 | 0.05 |
Positive family history for spondyloarthritis, % | 417 | 32.0 | 40.5 | 0.08 | 393 | 32.1 | 42.0 | 0.05 |
Prior sacroiliitis on MRI, % | 477 | 52.9 | 58.7 | 0.23 | 453 | 53.9 | 58.5 | 0.34 |
BASDAI | 430 | 4.6 (2.2) | 5.3 (2.1) | 0.003 | 412 | 4.6 (2.2) | 5.1 (2.1) | 0.02 |
• BASDAI 1 (fatigue) | 436 | 4.7 (2.8) | 6.0 (2.4) | < 0.001 | 418 | 4.7 (2.8) | 5.9 (2.4) | < 0.001 |
• BASDAI 2 (back pain) | 436 | 5.9 (2.7) | 6.5 (2.5) | 0.03 | 418 | 5.9 (2.7) | 6.3 (2.5) | 0.10 |
• BASDAI 3 (joint pain/swelling) | 435 | 3.6 (3.1) | 4.2 (3.1) | 0.04 | 417 | 3.6 (3.1) | 4.1 (3.1) | 0.07 |
• BASDAI 4 (enthesitis) | 433 | 4.2 (3.3) | 5.0 (3.1) | 0.02 | 415 | 4.2 (3.3) | 4.8 (3.0) | 0.04 |
• BASDAI 5 (intensity of morning stiffness) | 434 | 5.2 (3.0) | 5.4 (3.1) | 0.65 | 416 | 5.3 (3.0) | 5.2 (3.1) | 0.96 |
• BASDAI 6 (duration of morning stiffness) | 433 | 4.0 (2.9) | 4.1 (2.9) | 0.68 | 415 | 4.0 (2.9) | 4.0 (2.9) | 0.99 |
Physician Global Assessment | 481 | 3.7 (2.2) | 3.8 (2.0) | 0.49 | 412 | 3.7 (2.2) | 3.7 (2.0) | 0.86 |
Patient Global Assessment | 430 | 5.3 (2.9) | 5.6 (2.8) | 0.27 | 412 | 5.3 (2.9) | 5.5 (2.8) | 0.54 |
ASDAS | 402 | 2.9 (1.0) | 2.9 (0.9) | 0.23 | 386 | 2.9 (1.0) | 2.9 (0.9) | 0.49 |
CRP (mg/l), median (IQR) | 463 | 4.0 (1.0; 8.0) | 4.0 (2.0; 8.0) | 0.86 | 441 | 4.0 (1.1; 8.0) | 4.0 (2.0; 8.0) | 0.96 |
Elevated CRP, % | 459 | 26.5 | 26.6 | 1.00 | 437 | 26.5 | 26.1 | 1.00 |
BASFI | 435 | 2.8 (2.4) | 3.1 (2.5) | 0.16 | 416 | 2.8 (2.4) | 2.9 (2.4) | 0.54 |
BASMI | 473 | 1.3 (1.4) | 1.3 (1.3) | 0.98 | 449 | 1.4 (1.4) | 1.3 (1.2) | 0.72 |
EQ-5D | 431 | 61.4 (22.5) | 59.7 (20.1) | 0.34 | 412 | 61.3 (22.6) | 61.2 (19.4) | 0.78 |
IBP according to ASAS, % | 462 | 80.5 | 77.3 | 0.43 | 437 | 80.6 | 77.0 | 0.41 |
Spinal MRI inflammation, % | 476 | 26.9 | 24.9 | 0.67 | 452 | 26.9 | 23.6 | 0.45 |
Spinal radiographic changes, % | 476 | 6.3 | 3.6 | 0.20 | 452 | 5.9 | 3.0 | 0.17 |
Current peripheral arthritis,% | 489 | 35.8 | 39.2 | 0.46 | 464 | 36.0 | 38.9 | 0.57 |
Number of swollen joints | 481 | 0.7 (1.9) | 0.9 (2.3) | 0.38 | 457 | 0.7 (1.9) | 0.7 (1.8) | 0.54 |
Current enthesitis, % | 483 | 64.0 | 79.6 | < 0.001 | 459 | 63.8 | 78.3 | < 0.001 |
Modified MASES | 481 | 1.9 (2.5) | 3.2 (3.4) | < 0.001 | 457 | 1.8 (2.5) | 2.9 (3.1) | < 0.001 |
Co-morbid fibromyalgia, % | 307 | 2.7 | 13.1 | < 0.001 | – | – | – | – |
Dactylitis ever, % | 492 | 10.9 | 11.4 | 0.89 | 468 | 10.6 | 12.0 | 0.66 |
Uveitis ever, % | 434 | 18.1 | 13.1 | 0.18 | 410 | 18.4 | 12.9 | 0.14 |
Psoriasis ever, % | 373 | 9.1 | 9.1 | 1.00 | 351 | 9.3 | 8.4 | 0.85 |
Inflammatory bowel disease ever, % | 427 | 6.0 | 7.9 | 0.46 | 403 | 5.6 | 8.2 | 0.33 |
Taking NSAIDs, % | 471 | 87.3 | 90.4 | 0.31 | 447 | 87.6 | 89.6 | 0.55 |
Taking methotrexate, % | 495 | 5.2 | 10.2 | 0.04 | 470 | 5.3 | 9.9 | 0.08 |
Taking sulfasalazine, % | 495 | 4.8 | 6.1 | 0.56 | 470 | 4.8 | 6.2 | 0.55 |
Taking TNFi, % | 495 | 14.7 | 15.5 | 0.90 | 470 | 14.5 | 15.2 | 0.90 |
Ever TNFi, % | 495 | 68.0 | 72.0 | 0.78 | 470 | 67.4 | 70.8 | 0.80 |
Current smoking, % | 432 | 32.0 | 30.2 | 0.75 | 413 | 32.0 | 28.3 | 0.45 |
Body mass index | 483 | 25.7 (3.9) | 24.3 (4.5) | < 0.001 | 458 | 25.6 (3.9) | 24.1 (4.2) | < 0.001 |
Education, % | 462 | 0.46 | 440 | 0.52 | ||||
• Compulsory | 15.8 | 19.8 | 15.2 | 18.3 | ||||
• Vocational | 56.7 | 51.8 | 57.4 | 52.4 | ||||
• University | 27.4 | 28.3 | 27.5 | 29.3 | ||||
Absenteeism within last year, % | 389 | 53.9 | 44.0 | 0.12 | 372 | 53.9 | 43.2 | 0.10 |