Fig. 1

LSM change (95% CI) from baseline to week 24 on HRQoL endpoints by IL-6 tertile^† and overall population for SF-36 PCS scores (a), AM-stiffness scores (b), and FACIT-fatigue scores (c). Adalimumab: low tertile, n = 45; medium tertile, n = 53; high tertile, n = 54. Sarilumab: low tertile, n = 55; medium tertile, n = 47; high tertile, n = 46. AM-stiffness duration of morning stiffness visual analog scale, CFB change from baseline, CI confidence interval, FACIT-fatigue Functional Assessment of Chronic Illness Therapy-fatigue, HRQoL health-related quality of life, IL-6 interleukin-6, LSM least squares mean, LSM∆ LSM difference between sarilumab and adalimumab, SF-36 Short Form 36, PCS physical component summary, VAS visual analog scale. ^†Low (1.6–7.1 pg/mL), medium (7.2–39.5 pg/mL), high (39.6–692.3 pg/mL). *Nominal interaction p value versus low IL-6 tertile < 0.05