Fig. 1From: Empirical evidence of disease activity thresholds used to indicate need for major therapeutic change in US veterans with rheumatoid arthritisYouden Index and empirical thresholds. ROC curves of disease activity measure thresholds for the likelihood to initiate MTC and empiric thresholds are shown. Empirical optimal thresholds with 95% CI, Youden indices, sensitivity and specificity at each threshold, and the AUC for the ROC curves are reported in the table. 95% CI, 95% confidence interval; AUC, area under the curve; DAS28, Disease Activity Score for 28 joints; CDAI, Clinical Disease Activity Index; MTC, major therapeutic change; ROC, receiver operating characteristic curves; RAPID3, Routine Assessment of Patient Index Data 3Back to article page