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Table 1 Demographic and clinical characteristics

From: Empirical evidence of disease activity thresholds used to indicate need for major therapeutic change in US veterans with rheumatoid arthritis

 

Study population (1776 patients; 12,094 visits)

With MTC (v = 3077)

Without MTC (v = 9017)

Age, mean years (SD) [95% CI]

63.1 (11.0) [62.7–63.5]

65.6 (10.7) [65.4–65.9]

Male sex, n (%) [95% CI]

2784 (90.5) [89.4–91.5]

8190 (90.8) [90.2–91.4]

Caucasian race, n (%) [95% CI]

2349 (76.3) [74.8–77.8]

7135 (79.1) [78.3–80.0]

RA duration, mean years (SD) [95% CI]

14.0 (11.6) [13.9–14.7]

15.7 (11.7) [15.5–16.0]

RDCI score mean (SD) [95% CI]

2.3 (1.5) [2.2–2.3]

2.3 (1.5) [2.2–2.3]

RF status, n (%) [95% CI]

 Positive

2743 (89.1) [88.0–90.2]

8005 (88.8) [88.1–89.4]

 Negative

328 (10.7) [9.6–11.8]

995 (11.0) [10.4–11.7]

 Missing

6 (0.2) [0.1–0.4]

17 (0.2) [0.1–0.3]

ACPA status, n (%) [95% CI]

 Positive

2572 (83.6) [82.2–84.9]

7491 (83.1) [82.3–83.8]

 Negative

497 (16.2) [14.9–17.5]

1501 (16.6) [15.9–17.4]

 Missing

8 (0.3) [0.1–0.5]

25 (0.3) [0.2–0.4]

DAM stability, n (%) [95% CI]

 Better or no change

2146 (69.7) [68.1–71.4]

6299 (69.9) [68.9–70.8]

 Worse

931 (30.3) [28.6–31.9]

2718 (30.1) [29.2–31.1]

Recent dispensing episodesa, n (%) [95% CI]

 bDMARD

348 (11.3) [10.2–12.5]

1396 (15.5) [14.7–16.2]

 csDMARD

646 (21.0) [19.6–22.5]

2710 (30.1) [29.1–31.0]

 Prednisone

308 (10.0) [9.0–11.1]

731 (8.1) [7.6–8.7]

Established dispensing episodesb, n (%) [95% CI]

 bDMARD

1171 (38.1) [36.3–39.8]

3808 (42.2) [41.2–43.3]

 csDMARD

2609 (84.8) [83.5–86.0]

8104 (89.9) [89.2–90.5]

 Prednisone

1628 (52.9) [51.1–54.7]

3580 (39.7) [38.7–40.7]

Baseline MTC before index visit, n (%) [95% CI]

 8–30 days

45 (1.5) [1.1–2.0]

137 (1.5) [1.3–1.8]

 8–60 days

161 (5.2) [4.5–6.1]

539 (6.0) [5.5–6.5]

 8–90 days

292 (9.5) [8.5–10.6]

1134 (12.6) [11.9–13.3]

  1. ACPA anti-cyclic citrullinated peptide antibody, bDMARD biologic disease-modifying antirheumatic drug, csDMARD conventional synthetic disease-modifying antirheumatic drug, DAM disease activity measure, MTC major therapeutic change, SD standard deviation, 95% CI 95% confidence interval
  2. aRecent dispensing episodes were first dispensed between 8 and 30 days of eligible visit
  3. bEstablished dispensing episodes were dispensed between 8 and 370 days of eligible visit