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Table 2 Crude descriptive analysis of the frequency of MTC and ACR20 response by DAM and disease activity category for visits with ACR20 responses

From: Empirical evidence of disease activity thresholds used to indicate need for major therapeutic change in US veterans with rheumatoid arthritis

DAM category

Visits analyzed (7322 complete case visits)*

With MTC (v = 2113 visits)

Without MTC (v = 5209 visits)

RD (95% CI)

RR (95% CI)

Frequency

ACR20 response frequency (%)

Frequency

ACR20 response frequency (%)

Overall

2113

400 (18.9)

5209

360 (6.9)

12 (10.21–13.83)

2.7 (2.40–3.13)

DAS28

 Remission

253

4 (1.6)

1217

15 (1.2)

0.3 (− 1.31–2.01)

1.3 (0.43–3.83)

 Low

227

9 (4.0)

876

20 (2.3)

1.7 (− 1.04–4.41)

1.7 (0.8–3.76)

 Moderate

946

157 (16.6)

2284

183 (8.0)

8.6 (5.96–11.2)

2.1 (1.7–2.53)

 High

687

230 (33.5)

832

142 (17.1)

16.4 (12.05–20.77)

2.0 (1.63–2.36)

CDAI

 Remission

90

0

500

0

0

0

 Low

397

9 (2.3)

1759

34 (1.9)

0.3 (− 1.27–1.93)

1.2 (0.57–2.43)

 Moderate

776

135 (17.4)

1902

154 (8.1)

9.3 (6.36–12.24)

2.1 (1.73–2.67)

 High

850

256 (30.1)

1048

172 (16.4)

13.7 (9.89–17.52)

1.8 (1.55–2.18)

RAPID3

 Remission

108

3 (2.8)

444

9 (2.0)

0.8 (− 2.61–4.12)

1.4 (0.38–4.98)

 Low

167

16 (9.6)

684

30 (4.4)

5.2 (0.47–9.92)

2.2 (1.22–3.91)

 Moderate

526

82 (15.6)

1736

106 (6.1)

9.5 (6.19–12.78)

2.6 (1.95–3.35)

 High

1312

299 (22.8)

2345

215 (9.2)

13.6 (11.07–16.17)

2.5 (2.11–2.92)

  1. 95% CI 95% confidence interval, ACR20 20% improvement in American College of Rheumatology criteria, CDAI Clinical Disease Activity Index, DAM disease activity measure, DAS28 Disease Activity Score for 28 joints, MTC major therapeutic change, RAPID3 Routine Assessment of Patient Index Data 3, RD risk difference, RR risk ratio
  2. *The full population included 12,094 visits; the results in this table are based on only complete cases (4772 visits had missing ACR20 responses)