Table 3 Crude descriptive analysis of the frequency of MTC and ACR20 response by DAM and disease activity category combined with empirical threshold
DAM category | Visits analyzed (7322 complete case visits)* | |||||
|---|---|---|---|---|---|---|
With MTC (v = 2113 visits) | Without MTC (v = 5209 visits) | RD (95% CI) | RR (95% CI) | |||
Frequency | ACR20 response frequency (%) | Frequency | ACR20 response frequency (%) | |||
Overall | 2113 | 400 (18.9) | 5209 | 360 (6.9) | 12 (10.21–13.83) | 2.7 (2.40–3.13) |
DAS28 | ||||||
Remission and low (< 3.20) | 480 | 13 (2.7) | 2093 | 35 (1.7) | 1.0 (− 0.52–2.59) | 1.6 (0.86–3.04) |
Low moderate (3.20–4.02) | 366 | 43 (11.8) | 1154 | 57 (4.9) | 6.8 (3.28–10.34) | 2.4 (1.63–3.47) |
High moderate (4.03–5.10) | 580 | 114 (19.7) | 1130 | 126 (11.2) | 8.5 (4.79–12.22) | 1.8 (1.4–2.22) |
High (> 5.10) | 687 | 230 (33.5) | 832 | 142 (17.1) | 16.4 (12.05–20.77) | 2.0 (1.63–2.36) |
CDAI | ||||||
Remission and low (< 10.0) | 487 | 9 (1.9) | 2259 | 34 (1.5) | 0.3 (− 0.95–1.64) | 1.2 (0.59–2.54) |
Low moderate (10.0–12.9) | 194 | 18 (9.3) | 652 | 36 (5.5) | 3.8 (− 0.69–8.2) | 1.7 (0.98–2.89) |
High moderate (13.0–22.0) | 582 | 117 (20.1) | 1250 | 118 (9.4) | 10.7 (7.03–14.3) | 2.1 (1.68–2.7) |
High (> 22.0) | 850 | 256 (30.1) | 1048 | 172 (16.4) | 13.7 (9.89–17.52) | 1.8 (1.55–2.18) |
RAPID3 | ||||||
Remission and low (< 2.00) | 275 | 19 (6.9) | 1128 | 39 (3.5) | 3.5 (0.27–6.63) | 2.0 (1.17–3.4) |
Low moderate (2.00–3.81) | 452 | 73 (16.2) | 1555 | 94 (6.1) | 10.1 (6.51–13.7) | 2.7 (2.00–3.56) |
High moderate (3.82–4.00) | 74 | 9 (12.2) | 181 | 12 (6.6) | 5.5 (− 2.75–13.81) | 1.8 (0.81–4.17) |
High (> 4.00) | 1312 | 299 (22.8) | 2345 | 215 (9.2) | 13.6 (11.07–16.17) | 2.5 (2.11–2.92) |