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Table 2 Association of TERT and DSP with MPA and MPO-AAV

From: Association of TERT and DSP variants with microscopic polyangiitis and myeloperoxidase-ANCA positive vasculitis in a Japanese population: a genetic association study

 

TERT rs2736100A

DSP rs2076295G

n (AF)

P

Pc

OR (95% CI)

n (AF)

P

Pc

OR (95% CI)

AAV

 MPA

427 (0.678)

2.3 × 10−4

0.0023

1.38 (1.16–1.64)

351 (0.557)

6.9 × 10−4

0.0069

1.32 (1.12–1.55)

 GPA

142 (0.597)

0.82

1

0.97 (0.75–1.26)

130 (0.546)

0.074

0.74

1.26 (0.98–1.64)

 EGPA

101 (0.692)

0.031

0.31

1.47 (1.03–2.09)

77 (0.527)

0.34

1

1.17 (0.85–1.63)

 MPO-AAV

577 (0.669)

1.5 × 10−4

0.0015

1.33 (1.15–1.54)

471 (0.545)

0.0011

0.011

1.26 (1.10–1.45)

 PR3-AAV

93 (0.694)

0.034

0.34

1.49 (1.03–2.15)

78 (0.582)

0.03

0.3

1.46 (1.04–2.07)

Controls

 HCa

965 (0.615)

   

791 (0.505)

   

 4.7KJPNb

5747 (0.602)

   

4628 (0.485)

   

 All controls

6712 (0.604)

  

Referent

5419 (0.488)

  

Referent

  1. P values were calculated by chi-square test in comparison between each AAV subset and all controls. Correction for multiple testing was done by Bonferroni correction. Corrected P values (Pc) were calculated by multiplying uncorrected P values by 10. Significant association after correction for multiple testing (Pc < 0.05) is shown in bold
  2. AAV ANCA-associated vasculitis, n allele count, AF allele frequency, MPA microscopic polyangiitis, GPA granulomatosis with polyangiitis, EGPA eosinophilic granulomatosis with polyangiitis, MPO-AAV myeloperoxidase (MPO)-ANCA positive vasculitis, PR3-AAV proteinase 3 (PR3)-ANCA positive vasculitis, HC healthy controls, Pc corrected P values, OR odds ratio, 95% CI 95% confidence interval
  3. aHealthy controls recruited by our research group
  4. bAllele data in 4.7KJPN was obtained from the Japanese Multi Omics Reference Panel (jMorp) [22, 23]
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Arthritis Research & Therapy

ISSN: 1478-6362

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