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Table 3 Association of TERT and DPS with AAV in female and male individuals

From: Association of TERT and DSP variants with microscopic polyangiitis and myeloperoxidase-ANCA positive vasculitis in a Japanese population: a genetic association study

 

TERT rs2736100A

DSP rs2076295G

n (AF)

P

OR (95% CI)

n (AF)

P

OR (95% CI)

Female

 MPA

260 (0.677)

0.0014

1.43 (1.15–1.78)

198 (0.516)

0.35

1.10 (0.90–1.36)

 MPO-AAV

358 (0.670)

6.0 × 10−4

1.39 (1.15–1.67)

269 (0.502)

0.62

1.05 (0.88–1.25)

 Controlsa

3708 (0.595)

 

Referent

3062 (0.491)

 

Referent

Male

 MPA

167 (0.679)

0.049

1.32 (1.00–1.73)

153 (0.622)

2.3 × 10−5

1.76 (1.35–2.29)

 MPO-AAV

219 (0.668)

0.064

1.25 (0.99–1.58)

202 (0.616)

3.5 × 10−6

1.71 (1.36–2.15)

 Controlsa

3003 (0.616)

 

Referent

2355 (0.484)

 

Referent

  1. P values were calculated by chi-square test in comparison between each AAV subset and controls
  2. AAV ANCA-associated vasculitis, MPA microscopic polyangiitis, MPO-AAV myeloperoxidase (MPO)-ANCA positive vasculitis, n allele count, AF allele frequency, OR odds ratio, 95% CI 95% confidence interval
  3. aData in controls include allele data in healthy controls and 4.7KJPN obtained from the Japanese Multi Omics Reference Panel (jMorp) [22, 23]
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Arthritis Research & Therapy

ISSN: 1478-6362

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