Fig. 2

Distribution of memory T helper (Th) cell subsets in paired blood and synovial fluid (SF) from patients with rheumatoid arthritis (RA). a Comparison of the proportions of total CD4⁺ lymphocytes, CD45RA^negCD4⁺ memory T cells and CXCR3⁺CD4⁺ T cells in blood and SF of patients with RA (n = 8). b OPLS-DA column loading plots showing the association of CD45RA^neg Th subset proportions (X-variables) to either SF or blood (Y-variables). c Comparison of the proportions of TPh, PD-1^highTFh, CXCR3⁺Th2, Th1, CXCR3⁺Th17, Th1Th17, PD-1⁺ TFh, Th17 and Th2 subsets of CD45RA^negCD4⁺ lymphocytes in blood and SF (gating strategy shown in Supplementary Figure 1). Horizontal bars indicate median. P value denotes the statistical significance of the difference between T cell proportions in blood and SF (Wilcoxon matched-pairs signed rank)