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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: T helper cells in synovial fluid of patients with rheumatoid arthritis primarily have a Th1 and a CXCR3+Th2 phenotype

Fig. 5

Fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis (RA) produce proinflammatory cytokines and chemokines when stimulated with T helper-associated cytokines. a The median fold change in IL-6, GM-CSF, CCL2, CXCL1, CXCL8, CCL11 and CXCL10 concentration in supernatants of stimulated as compared to unstimulated FLS. b IL-6 and GM-CSF levels and c CCL2, CXCL1, IL-8, CCL11 and CXCL10 levels in cell culture supernatant of RA (n = 7) FLS stimulated with IL-4, IL-13, IL-17A, IFNγ or TNF as measured by bead-based immunoassays and ELISA. Lines within boxes indicate the median. P value denotes the statistical significance of the difference between respective cytokine stimulus and media controls (Friedman test followed by Dunn’s multiple comparisons test)

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Arthritis Research & Therapy

ISSN: 1478-6362

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