Table 5 Parameters associated with the metabolic syndrome at baseline (BL) and after weight loss at 6 months (M6), 12 months (M12) and 24 months (M24) in patients with psoriatic arthritis (PsA) and obesity. Values are median and inter-quartile range (IQR)
BL N = 39 | M6 N = 39 | M12 N = 39 | M24 N = 35 | BL-M6 p-value N = 39 | BL-M12 p-value N = 39 | BL-M24 p-value N = 35 | |
|---|---|---|---|---|---|---|---|
BMI kg/m2 | 35.2 (34.0–37.8) | 29.7 (26.2–31.4) | 30.5 (28.0–33.0) | 32.3 (30.2–35.4) | < 0.001 | < 0.001 | < 0.001 |
Waistline cm | 115 (112–122) | 95 (8–102) | 97.5 (90–105) | 107 (96–113) | < 0.001 | < 0.001 | < 0.001 |
BP systolic mmHg | 127.5 (115–136) | 120 (102.5–130) | 121 (113.5–140) | 124 (115–145) | < 0.001 | 0.410 | 0.701 |
BP diastol mmHg | 77.5 (70–82.5) | 70 (62.5–77.5) | 72.5 (65–82.5) | 75 (70–86) | < 0.001 | 0.073 | 0.891 |
S-TC mmol/L | 5.5 (4.6–6.2) | 4.9 (4.4–5.7) | 5.4 (4.7–5.9) | 5.6 (4.6–6.0) | 0.019 | 0.508 | 0.227 |
S-LDL mmol/L | 3.6 (3.0–4.4) | 3.2 (2.6–3.9) | 3.4 (2.8–4.0) | 3.9 (2.8–4.5) | 0.003 | 0.468 | 0.596 |
S- HDL mmol/L | 1.4 (1.1–1.6) | 1.4 (1.2–1.6) | 1.65 (1.4–2.0) | 1.6 (1.3–1.7) | 0.001 | < 0.001 | 0.005 |
S- TG mmol/L | 1.6 (1.2–2.4) | 1.1 (0.9–1.6) | 1.2 (1.0–1.7) | 1.4 (1.0–2.1) | < 0.001 | < 0.001 | 0.007 |
HbA1c mmol/mol | 35.5 (32.0–37.2) | 32.5 (29.8–36.0) | 34 (31–36) | 35 (32–38) | < 0.001 | 0.002 | 0.203 |
S-glucose mmol/L | 5.7 (5.3–6.2) | 5.4 (5.1–5.8) | 5.5 (5.0–5.9) | 5.6 (5.2–6.2) | < 0.001 | 0.006 | 0.055 |
Creatinine μmol/L | 75 (64–84) | 70 (62–86) | 72 (60–81) | 74 (58–83) | 0.066 | 0.041 | 0.009 |
ALT μkat/L | 0.52 (0.41–0.68) | 0.45 (0.36–0.62) | 0.42 (0.31–0.55) | 0.45 (0.31–0.58) | 0.143 | 0.015 | 0.075 |
Mets n (%) | 30 (76.9) | 14 (35.9) | 15 (38.5) | 21 (60) | < 0.001 | < 0.001 | 0.118 |