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Table 5 Parameters associated with the metabolic syndrome at baseline (BL) and after weight loss at 6 months (M6), 12 months (M12) and 24 months (M24) in patients with psoriatic arthritis (PsA) and obesity. Values are median and inter-quartile range (IQR)

From: Weight loss is associated with sustained improvement of disease activity and cardiovascular risk factors in patients with psoriatic arthritis and obesity: a prospective intervention study with two years of follow-up

  BL
N = 39
M6
N = 39
M12
N = 39
M24
N = 35
BL-M6
p-value
N = 39
BL-M12
p-value
N = 39
BL-M24
p-value
N = 35
BMI kg/m2 35.2 (34.0–37.8) 29.7 (26.2–31.4) 30.5 (28.0–33.0) 32.3 (30.2–35.4) < 0.001 < 0.001 < 0.001
Waistline cm 115 (112–122) 95 (8–102) 97.5 (90–105) 107 (96–113) < 0.001 < 0.001 < 0.001
BP systolic mmHg 127.5 (115–136) 120 (102.5–130) 121 (113.5–140) 124 (115–145) < 0.001 0.410 0.701
BP diastol mmHg 77.5 (70–82.5) 70 (62.5–77.5) 72.5 (65–82.5) 75 (70–86) < 0.001 0.073 0.891
S-TC mmol/L 5.5 (4.6–6.2) 4.9 (4.4–5.7) 5.4 (4.7–5.9) 5.6 (4.6–6.0) 0.019 0.508 0.227
S-LDL mmol/L 3.6 (3.0–4.4) 3.2 (2.6–3.9) 3.4 (2.8–4.0) 3.9 (2.8–4.5) 0.003 0.468 0.596
S- HDL mmol/L 1.4 (1.1–1.6) 1.4 (1.2–1.6) 1.65 (1.4–2.0) 1.6 (1.3–1.7) 0.001 < 0.001 0.005
S- TG mmol/L 1.6 (1.2–2.4) 1.1 (0.9–1.6) 1.2 (1.0–1.7) 1.4 (1.0–2.1) < 0.001 < 0.001 0.007
HbA1c mmol/mol 35.5 (32.0–37.2) 32.5 (29.8–36.0) 34 (31–36) 35 (32–38) < 0.001 0.002 0.203
S-glucose mmol/L 5.7 (5.3–6.2) 5.4 (5.1–5.8) 5.5 (5.0–5.9) 5.6 (5.2–6.2) < 0.001 0.006 0.055
Creatinine μmol/L 75 (64–84) 70 (62–86) 72 (60–81) 74 (58–83) 0.066 0.041 0.009
ALT μkat/L 0.52 (0.41–0.68) 0.45 (0.36–0.62) 0.42 (0.31–0.55) 0.45 (0.31–0.58) 0.143 0.015 0.075
Mets n (%) 30 (76.9) 14 (35.9) 15 (38.5) 21 (60) < 0.001 < 0.001 0.118
  1. ALT = alanine transaminase, BMI = Body Mass Index, BP = blood pressure, HbA1c = glycosylated hemoglobin, HDL = high-density lipoprotein cholesterol, LDL = low-density lipoprotein cholesterol, S– =serum, TC = total cholesterol, TG = triglycerides, Mets = metabolic syndrome