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Table 2 Experimentally verified miRNAs associated with IDD

From: Emerging evidence on noncoding-RNA regulatory machinery in intervertebral disc degeneration: a narrative review

MiRNA Expression Target(s) Functions Publication year References
MiR-155 FADD, caspase-3
ERK1/2, TCF7L2, MMP-16
↓NP cell apoptosis
↓ECM degradation
2011
2016–2018
[18]
[33,34,35]
MiR-21 ↓*
PTEN
PTEN, PDCD4
PTEN
↓NP cell apoptosis
↑NP cell proliferation
↑ECM degradation
2018
2014,2016
2018
[36]
[21, 37]
[38]
MiR-27a PI3K ↑NP cell apoptosis 2013 [39]
MiR-499a-5p SOX4 ↓NP cell apoptosis
↓ECM degradation
2019
2019
[40]
[40]
MiR-494 SOX9, JunD
SOX9
↑NP cell apoptosis
↑ECM degradation
2015,2017
2017
[41, 42]
[41]
MiR-30d SOX9 ↑NP cell apoptosis
↑ECM degradation
2018
2018
[43]
[43]
MiR-222-3p CDKN1B ↑NP cell apoptosis
↓NP cell proliferation
↑ECM degradation
2019
2019
2019
[44]
[44]
[44]
MiR-15a MAP3K9 ↑NP cell apoptosis
↓NP cell proliferation
2017
2017
[45]
[45]
MiR-486-5p FOXO1 ↓NP cell apoptosis
↓ECM degradation
↓inflammation
2019
2019
2019
[46]
[46]
[46]
MiR-200c XIAP ↑NP cell apoptosis
↑ECM degradation
2018
2018
[23]
[23]
MiR-328-5p ERBB2 ↑NP cell apoptosis 2018 [47]
MiR-34a GDF5
Bcl-2
↑ECM degradation
↑CEP cell apoptosis
2016
2015
[48]
[7]
MiR-143 Bcl-2 ↑NP cell apoptosis 2017 [49]
MiR-532 Bcl-9 ↑NP cell apoptosis 2018 [50]
MiR-125a TP53INP1 ↓NP cell apoptosis 2016 [51]
MiR-221 ERα
FOXO3, TRPS1
BMP-Smad pathway
↑CEP cell apoptosis
↑ECM degradation
↑inflammation
↓chondrogenesis
↓AF cell osteogenic differentiation
2018
2018
2018
2018
2016
[52]
[52]
[52]
[53]
[54]
MiR-138-5p SIRT1 ↑NP cell apoptosis 2016 [55]
MiR-145 ADAM17 ↓NP cell apoptosis
↓ECM degradation
2019
2019
[56]
[56]
MiR-573 Bax ↓NP cell apoptosis 2019 [57]
MiR-153-3p ATG5 ↓NP cell autophagy 2019 [58]
MiR-106a-5p ATG7 ↑AF cell apoptosis
↓AF cell proliferation
2019
2019
[8]
[8]
MiR-10b HOXD10 ↑NP cell proliferation 2013 [59]
MiR-96 ARID2 ↑NP cell proliferation 2017 [60]
MiR-184 GAS1 ↑NP cell proliferation 2017 [61]
MiR-2355-5p ERFFI1 ↑NP cell proliferation
↑inflammation
2019
2019
[62]
[62]
MiR-365 HDAC4 ↑CEP cell proliferation 2019 [63]
MiR-125b-1-3p TSHZ3 ↓NP cell proliferation 2018 [64]
MiR-665 GDF5 ↑NP cell proliferation
↑ECM degradation
2018
2018
[65]
[65]
MiR-7 GDF5 ↑ECM degradation 2016 [66]
MiR-132 GDF5 ↑ECM degradation 2017 [67]
MiR-15b SMAD3 ↑ECM degradation 2017 [68]
MiR-20a ANKH ↑CEP chondrocyte calcification 2016 [69]
MiR-377 ADAMTS5 ↑ECM degradation 2013 [70]
MiR-202-3p MMP1 ↓ECM degradation 2019 [71]
MiR-17-3p MMP2 ↓ECM degradation
↓NP cell apoptosis
↑NP cell proliferation
2018
2018
2018
[72]
[72]
[72]
MiR-93 MMP3 ↓ECM degradation 2015 [73]
MiR-133a MMP9 ↓ECM degradation 2016 [74]
MiR-27b MMP13 ↓ECM degradation 2016 [75]
MiR-127-5p MMP13 ↓ECM degradation 2017 [76]
MiR-193a-3p MMP14 ↓ECM degradation 2016 [77]
MiR-98 IL-6 ↓ECM degradation 2016 [78]
MiR-100 FGFR3 ↑ECM degradation 2015 [79]
MiR-146a Not clear** TRAF6 ↑ECM degradation
↓inflammation
2015
2015,2017
[22]
[22, 80]
MiR-210 ATG7 ↑ECM degradation 2017 [81]
MiR-194 CHSY1/2/3 ↑ECM degradation 2017 [82]
MiR-515 CHSY1/2/3 ↑ECM degradation 2017 [82]
MiR-3150a-3p ACAN ↑ECM degradation 2018 [83]
MiR-640 LRP1,β-catenin, EP300 ↑inflammation 2019 [84]
MiR-140-5p TLR4 ↓inflammation 2018 [85]
  1. The expression, targets, and functions of miRNAs related to IDD were displayed in Table 2. “↓” represents downregulation, while “↑” represents upregulation
  2. *Decrease in apoptotic NP cells.**It is reported that miR-146a is significantly downregulated in the PBMCs of IDD patients, but its expression in NP cells is unclear [80]