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Table 3 Experimentally verified circRNAs associated with IDD

From: Emerging evidence on noncoding-RNA regulatory machinery in intervertebral disc degeneration: a narrative review

CircRNA Expression Target miRNA Functions Publication year References
CircVMA21 miR-200c ↓NP cell apoptosis
↓ECM degradation
2018
2018
[23]
[23]
Circ-GRB10 miR-328-5p ↓NP cell apoptosis 2018 [47]
CircSEMA4B miR-431 ↓NP cell proliferation
↓ECM degradation
2018
2018
[96]
[96]
CircRNA_104670 miR-17-3p ↑NP cell apoptosis
↓NP cell proliferation
↑ECM degradation
2018
2018
2018
[72]
[72]
[72]
Circ-4099 miR-616-5p ↓ECM degradation
↓Inflammation
2018
2018
[94]
[94]
  1. The expression, targets, and functions of circRNAs related to IDD were displayed in Table 3. “↓” represents downregulation, while “↑” represents upregulation