Emerging evidence on noncoding-RNA regulatory machinery in intervertebral disc degeneration: a narrative review

Table 3 Experimentally verified circRNAs associated with IDD

CircRNA	Expression	Target miRNA	Functions	Publication year	References
CircVMA21	↓	miR-200c	↓NP cell apoptosis ↓ECM degradation	2018 2018	[23] [23]
Circ-GRB10	↓	miR-328-5p	↓NP cell apoptosis	2018	[47]
CircSEMA4B	↓	miR-431	↓NP cell proliferation ↓ECM degradation	2018 2018	[96] [96]
CircRNA_104670	↑	miR-17-3p	↑NP cell apoptosis ↓NP cell proliferation ↑ECM degradation	2018 2018 2018	[72] [72] [72]
Circ-4099	↑	miR-616-5p	↓ECM degradation ↓Inflammation	2018 2018	[94] [94]

The expression, targets, and functions of circRNAs related to IDD were displayed in Table 3. “↓” represents downregulation, while “↑” represents upregulation

ISSN: 1478-6362