TY - JOUR AU - Dalbeth, Nicola AU - Allan, Jordyn AU - Gamble, Gregory D. AU - Horne, Anne AU - Woodward, Owen M. AU - Stamp, Lisa K. AU - Merriman, Tony R. PY - 2020 DA - 2020/11/04 TI - Effect of body mass index on serum urate and renal uric acid handling responses to an oral inosine load: experimental intervention study in healthy volunteers JO - Arthritis Research & Therapy SP - 259 VL - 22 IS - 1 AB - High body mass index (BMI) is strongly associated with hyperuricaemia. It is unknown whether overweight and obesity influences serum urate primarily through increased urate production or reduced renal clearance of uric acid. The aim of this study was to determine the influence of BMI on the response to inosine, a purine nucleoside that functions as an intermediate in the purine salvage and degradation pathways. SN - 1478-6362 UR - https://doi.org/10.1186/s13075-020-02357-y DO - 10.1186/s13075-020-02357-y ID - Dalbeth2020 ER -