Fig. 1

Different RNA expression between progressors and non-progressors (a, b) and association between RNA expression of IL-7R (c) and IGF-1 (d) IA development. a, b Differences of RNA expression between patients who did and did not progress to inflammatory arthritis. RNA expression levels grouped by patients that progressed to IA during follow-up (dark blue dots) and those that did not progress (light blue dots). Patients are categorized into tertiles based on the gene expression levels to create three groups of equal size; lowest expression values below the gray square (e.g., high risk), expression levels within the gray square are of moderate risk, and patients with the lowest risk are depicted above the square. c, d Association between RNA expression of IL-7R (c) and IGF-1 (d) at presentation with clinically suspect arthralgia and development of inflammatory arthritis over time. Vertical lines indicate that a patient is censored. Patients were categorized into tertiles based on the gene expression levels to create three groups of equal size; lowest expression values, and thus the highest risk for IA development, are represent in purple; moderate risk in green and lowest risk in yellow. Visual representation of the data was restricted to 850 days follow-up since thereafter the numbers of patients was small