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Table 1 Associations of significant top genes at presentation with clinically suspect arthralgia and progression to IA

From: Gene expression identifies patients who develop inflammatory arthritis in a clinically suspect arthralgia cohort

 

Multivariable analysesa

Multivariable analysesb

Multivariable analysesc

Coefficient

exp (coef)

p value^

p value FDR

Coefficient

exp (coef)

p value

Coefficient

exp (coef)

p value

IFNG

− 0.38

0.68

< 0.001

0.019

PHEX

− 0.73

0.48

< 0.001

0.019

IGF-1

− 0.77

0.46

< 0.001

0.028

− 0.51

0.60

0.046

0.69

0.50

0.005

IL-7R

− 0.66

0.52

< 0.001

0.031

− 0.51

0.60

0.025

0.48

0.62

0.039

CD19

− 1.43

0.24

0.001

0.037

− 0.41

0.66

0.385

CCR7

− 1.33

0.26

0.002

0.037

− 0.41

0.67

0.603

  1. aMultivariable analyses were adjusted for age, gender, and assay plate. ^p values were significant after FDR correction
  2. bMultivariable analyses were adjusted for age, gender, assay plate, and genes (IGF-1, IL-7R, CD19, and CCR7; PHEX was not included because of high correlation with IGF-1; IFNG was not included because of low expression and insufficient replication of expression by qPCR)
  3. cMultivariable analysis: genes that were significantly associated with IA development in analysis b were also corrected for ACPA, CRP, and subclinical joint inflammation, in addition to age, gender, assay plate
  4. Abbreviation: exp. (coef) exponential coefficient