| Multivariable analysesa | Multivariable analysesb | Multivariable analysesc |
---|
Coefficient | exp (coef) | p value^ | p value FDR | Coefficient | exp (coef) | p value | Coefficient | exp (coef) | p value |
---|
IFNG | − 0.38 | 0.68 | < 0.001 | 0.019 | – | – | – | – | – | – |
PHEX | − 0.73 | 0.48 | < 0.001 | 0.019 | – | – | – | – | – | – |
IGF-1 | − 0.77 | 0.46 | < 0.001 | 0.028 | − 0.51 | 0.60 | 0.046 | 0.69 | 0.50 | 0.005 |
IL-7R | − 0.66 | 0.52 | < 0.001 | 0.031 | − 0.51 | 0.60 | 0.025 | 0.48 | 0.62 | 0.039 |
CD19 | − 1.43 | 0.24 | 0.001 | 0.037 | − 0.41 | 0.66 | 0.385 | – | – | – |
CCR7 | − 1.33 | 0.26 | 0.002 | 0.037 | − 0.41 | 0.67 | 0.603 | – | – | – |
- aMultivariable analyses were adjusted for age, gender, and assay plate. ^p values were significant after FDR correction
- bMultivariable analyses were adjusted for age, gender, assay plate, and genes (IGF-1, IL-7R, CD19, and CCR7; PHEX was not included because of high correlation with IGF-1; IFNG was not included because of low expression and insufficient replication of expression by qPCR)
- cMultivariable analysis: genes that were significantly associated with IA development in analysis b were also corrected for ACPA, CRP, and subclinical joint inflammation, in addition to age, gender, assay plate
- Abbreviation: exp. (coef) exponential coefficient