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Table 3 Cox regression analysis on the association of laboratory results with disease activity in follow-up visits. Results of Cox regression analysis were shown in this table, which analyzed the association of ESR, hsCRP, IL-6, and TNFα with inactive disease or relapse in follow-up visits among 354 Takayasu’s arteritis patients who were followed-up

From: Association between acute phase reactants, interleukin-6, tumor necrosis factor-α, and disease activity in Takayasu’s arteritis patients

   Disease activity in follow-up visits p value HR (95% CI) Positive predictive value Negative predictive value
Inactive Active    (95% CI) (95% CI)
152 patients in active group at baseline
 Number of patients 120 32     
 ESR (≤ 20 mm/1st hour) 106 (86.2%) 17 (13.8%) < 0.001 1.00 53.6% (33.9–72.5%) 86.2% (78.8–91.7%)
  (> 20 mm/1st hour) 13 (46.4%) 15 (53.6%)   0.32 (0.18–0.58)   
 hsCRP (≤8 mg/L) 84 (91.3%) 8 (8.7%) < 0.001 1.00 42.7% (29.7-56. 8%) 91.3% (83.6–96.2%)
  (> 8 mg/L) 32 (57.1%) 24 (42.9%)   0.45 (0.30–0.68)   
 IL-6 (≤ 5.9 pg/ml) 65 (87.8%) 9 (12.2%) 0.006 1.00 33.3% (19.6–49.6%) 87.8% (78.2–94.3%)
  (> 5.9 pg/ml) 28 (66.7%) 14 (33.3%)   0.54 (0.34–0.84)   
 TNFα (≤ 8.1 pg/ml) 56 (76.7%) 17 (23.3%) 0.25 1.00 14.3% (5.4–28.5%) 76.7% (65.4–85.8%)
  (> 8.1 pg/ml) 36 (85.7%) 6 (14.3%)   1.31 (0.86–2.00)   
202 patients in inactive group at baseline
 Number of patients 96 106     
 ESR (≤ 20 mm/1sthr) 87 (57.3%) 65 (42.8%) < 0.001 1.00 80.9% (66.7–90.9%) 57.2% (49.0–65.2%)
  (> 20 mm/1sthr) 9 (19.2%) 38 (80.9%)   2.11 (1.41–3.16)   
 hsCRP (≤ 8 mg/L) 84 (56.8%) 64 (43.3%) < 0.001 1.00 82.2% (68.0–92.0%) 56.8% (48.4–64.9%)
  (> 8 mg/L) 8 (17.8%) 37 (82.2%)   2.13 (1.42–3.20)   
 IL-6 (≤5.9 pg/ml) 80 (61.1%) 51 (38.9%) < 0.001 1.00 78.1% (62.4–89.4%) 61.1% (52.2–69.5%)
  (> 5.9 pg/ml) 9 (22.0%) 32 (78.1%)   2.50 (1.60–3.91)   
 TNFα (≤8.1 pg/ml) 65 (63.1%) 38 (36.9%) < 0.001 1.00 65.2% (52.4–76.5%) 63.1% (53.0–72.4%)
  (> 8.1 pg/ml) 23 (34.9%) 43 (65.2%)   2.65 (1.69–4.15)   
  1. Abbreviation: HR hazard ratio, ESR erythrocyte sedimentation rate, hsCRP high sensitive C-reactive protein, IL-6 interleukin-6, TNFα tumor necrosis factor-α, CI confidence interval