Fig. 8

Efficiency of NP-MTX in the CIA model. a Temperature assessment, b paw thickness, and c clinical score in CIA-mice treated with either NP-MTX, MTX, or vehicle. Area under the curve of d IRT assessment, e paw thickness, and f clinical score measurements during the entire treatment period. The line graphs and columns show mean values +SD; n = 4. The P values between the means are as follows: ***P < 0.001; **P < 0.01; *P < 0.05; ns, non-significant