Early DAS response after DMARD-start increases probability of achieving sustained DMARD-free remission in rheumatoid arthritis

Table 2 Association of DAS_0–4m and DAS_4m with SDFR development within 7 years in ACPA-negative RA

	Multivariable logistics regression models
	OR (95%CI)	p value	OR (95%CI)	p value	OR (95%CI)	p value
Age (years)	1.01 (0.99–1.04)	0.37	1.02 (0.99–1.04)	0.38	1.02 (0.99–1.05)	0.13
Gender (male)	1.65 (0.80–3.39)	0.18	1.40 (0.66–2.97)	0.31	1.25 (0.61–2.57)	0.55
Symptom duration at diagnosis (≤ 12 weeks vs. > 12 weeks)	0.93 (0.45–1.88)	0.82	0.87 (0.42–1.79)	0.70	0.97 (0.49–1.93)	0.92
Baseline DAS	–		1.44 (1.00–2.08)	0.05	–
DAS_4 months	–		0.44 (0.29–0.68)	< 0.01	0.51 (0.35–0.75)	< 0.01
ΔDAS_0–4m	0.58 (0.42–0.80)	< 0.01	–		–

Legend: Multivariable logistic regression models in ACPA-negative RA (n = 184) with SDFR (yes/no) as dependent outcome variable. Multivariable analysis showed DAS levels at 4 months (DAS_4 months) were as predictive of SDFR as decrease in ΔDAS_0–4m, with and without incorporation of baseline DAS in the model
DAS disease activity score, BL baseline, CI confidence interval

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