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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Cyr61 synthesis is induced by interleukin-6 and promotes migration and invasion of fibroblast-like synoviocytes in rheumatoid arthritis

Fig. 1

Expression of IL-6 and Cyr61 in fibroblast-like synoviocytes (FLSs). a, b FLSs from osteoarthritis (OA; n = 4) or rheumatoid arthritis (RA, n = 4) patients. *p < 0.05 vs OA. c Synovial tissues from OA or RA patients. Original magnification × 400. d, e RA FLSs stimulated by IL-6/sIL-6R for 2 h. f, g FLSs stimulated by IL-6/s IL-6R (20 ng/mL) for the indicated periods. dg FLSs were incubated overnight in 1% FBS-containing medium before treatment with IL-6/sIL-6R. a, b, d, f Protein levels were determined by western blotting. e, g The mRNA levels of Cyr61 were determined through real time polymerase chain reaction. Values are means (± standard deviation) of at least three independent experiments. *p < 0.05, **p < 0.01 vs untreated cells. IL-6, interleukin-6; sIL-6R, soluble IL-6 receptor; FBS, foetal bovine serum

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