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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Cyr61 synthesis is induced by interleukin-6 and promotes migration and invasion of fibroblast-like synoviocytes in rheumatoid arthritis

Fig. 6

A schematic model for IL-6-stimulated Cyr61 expression and its role in FLS migration and invasion. IL-6 and soluble IL-6 receptor complex stimulate Cyr61 expression via the ERK/ EGR3 signalling pathway. Secreted Cyr61 protein activates FLSs in an autocrine or paracrine manner and the resulting increase in extracellular Cyr61 protein enhances FLS migration and invasion. IL-6, interleukin-6; FLS, fibroblast-like synoviocyte; ERK, extracellular signal-regulated kinase; EGR3, early growth response 3

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