Fig. 3

Hematoxylin and eosin (H&E) stained joint sections and semi-quantitative analysis of joint pathology scoring in mice with collagen-induced arthritis. a, b The arrows in the CI untreated control photomicrograph demonstrate high inflammatory milieu composed of polymorphous acute and chronic inflammation. The asterisks show extensive bone and cartilaginous destruction. On the contrary, the arrows in the CI (50 mg/kg once daily orally for 14 days)-treated joint tissues show preservation of the osteocartilaginous microanatomy with considerably less degenerative changes and inflammation. Scale bar = 100 μm. The figure is representative of 12 (6 = untreated control mice and 6 = CI-treated mice) separate experiments undertaken in different animals with similar results