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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Chebulinic acid is a safe and effective antiangiogenic agent in collagen-induced arthritis in mice

Fig. 5

Co-localization of CD31 and VEGFR-2 signaling pathway markers in both chebulinic acid (CI) untreated and CI-treated collagen-induced arthritis (CIA) mouse joint tissues. a Immunofluorescence staining and confocal microscope were used to collect co-staining of CD31 (green), and pVEGFR2 (red) in both untreated and CI-treated CIA mouse joint tissues. b Immunofluorescence staining and confocal microscope were used to collect co-staining of CD31 (green), and ESM 1 (red) in both untreated and CI-treated CIA mouse joint tissues. c Immunofluorescence staining and confocal microscope were used to collect co-staining of CD31 (green) and Apelin (red) in both untreated and CI-treated CIA mouse joint tissues. Scale bar = 100 μm. The figure is representative of 12 (6 = untreated control mice; 6 = CI-treated control mice) separate experiments undertaken in different animals with similar results

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