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Table 1 Toxicity Studies

From: Chebulinic acid is a safe and effective antiangiogenic agent in collagen-induced arthritis in mice

Parameters Untreated normal mice (n = 6) Chebulinic acid-treated normal mice (n = 6)
Hematological parameters
 Hemoglobin (g/dL) normal range, 11.0–15.1 13.0 + 1.02 13.0 + 0.8
 Neutrophils (k/μL) normal range, 0.1–2.4 0.9 + 0.01 1.0 + 0.04
 Platelet (k/μL) normal range, 592–2972 663.2 + 34.6 689.3 + 32.8
Liver function tests
 Alanine aminotransferase (ALT) [U/L] normal range, 16–50 24.3 + 1.8 24.7 + 2.0
 Aspartate aminotransferase (AST) [U/L] normal range, 34–102 63.0 + 8.4 59.3 + 7.2
 Total bilirubin (mg/dL) normal range, 0–0.3 0.23 + 0.01 0.21 + 0.01
Renal function tests
 Blood urea nitrogen (BUN) normal range, 14–32 20 + 2.0 19.5 + 1.5
 Creatinine normal range, 0.1–0.6 0.23 + 0.03 0.2 + 0.01