Table 1 Toxicity Studies
From: Chebulinic acid is a safe and effective antiangiogenic agent in collagen-induced arthritis in mice
Parameters | Untreated normal mice (n = 6) | Chebulinic acid-treated normal mice (n = 6) |
|---|---|---|
Hematological parameters | ||
Hemoglobin (g/dL) normal range, 11.0–15.1 | 13.0 + 1.02 | 13.0 + 0.8 |
Neutrophils (k/μL) normal range, 0.1–2.4 | 0.9 + 0.01 | 1.0 + 0.04 |
Platelet (k/μL) normal range, 592–2972 | 663.2 + 34.6 | 689.3 + 32.8 |
Liver function tests | ||
Alanine aminotransferase (ALT) [U/L] normal range, 16–50 | 24.3 + 1.8 | 24.7 + 2.0 |
Aspartate aminotransferase (AST) [U/L] normal range, 34–102 | 63.0 + 8.4 | 59.3 + 7.2 |
Total bilirubin (mg/dL) normal range, 0–0.3 | 0.23 + 0.01 | 0.21 + 0.01 |
Renal function tests | ||
Blood urea nitrogen (BUN) normal range, 14–32 | 20 + 2.0 | 19.5 + 1.5 |
Creatinine normal range, 0.1–0.6 | 0.23 + 0.03 | 0.2 + 0.01 |