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Table 2 LncRNAs involved in osteoclast generation

From: Noncoding RNAs in subchondral bone osteoclast function and their therapeutic potential for osteoarthritis

lncRNAs

Species

Up/down

Overall impact

Targets

Steps impacted

References

LncRNA-Jak3

RAW264.7

Up

Positive

NFATc1

Osteoclast differentiation

[39]

LncRNA-LINC00311

Rat osteoclasts

ND

Positive

DLL3

Induces proliferation and inhibits apoptosis of osteoclasts

[40]

LncRNA-AK131850

Mouse osteoclasts

Up

Positive

miR-93-5p

Promotes vasculogenesis of endothelial progenitor cells

[41]

LncRNA-TUG1

BMMs

Up

Positive

ND

Promotes the proliferation and inhibits the apoptosis of osteoclasts

[42]

LncRNA-AK077216

RAW264.7; BMMs

Up

Positive

NFATc1

Promotes osteoclast differentiation and enhances osteoclast bone resorption

[43]

LncRNA-CRNDE

Human osteoclasts

Up

Positive

ND

Promotes osteoclast proliferation

[44]

LncRNA- DANCR

hOCPs; RAW264.7

Up

Positive

FOXO1

Promotes osteoclastic differentiation

[45]

LncRNA RP11-498C9.17

PBMs

Down

ND

ND

Controls osteoclastogenesis.

[46]

LncRNA -MIRG

RAW264.7

Up

Positive

miR-1897

Promotes osteoclastic differentiation

[47]