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Table 3 Results of multiple regression analyses of each variable and JKOM pain score in each model

From: Obesity with radiological changes or depression was associated with worse knee outcome in general population: a cluster analysis in the Nagahama study

  Full model Reduced model 1 Reduced model 2 Reduced model 3
Standardized beta (95% CI) P value Standardized beta (95% CI) P value Standardized beta (95% CI) P value Standardized beta (95% CI) P value
Age 0.096 (0.052–0.129) < 0.0001 0.106 (0.065–0.134) < 0.0001 0.105 (0.065–0.133) < 0.0001
Sex − 0.038 (− 0.0543– 0.156) 0.2772
BMI 0.136 (0.146–0.284) < 0.0001 0.128 (0.139–0.26) < 0.0001 0.124 (0.135–0.256) < 0.0001 0.123 (0.133–0.255) < 0.0001
K/L grade 0.344 (1.999–2.509) < 0.0001 0.340 (1.977–2.460) < 0.0001 0.340 (1.982–2.465) < 0.0001 0.359 (2.104–2.583) < 0.0001
Muscle mass of lower extremity − 0.020 (− 0.309–0.168) 0.5634
BMD − 0.030 (− 0.346–0.390) 0.1187 − 0.025 (− 0.312–0.057) 0.1763 − 0.026 (− 0.314–0.054) 0.1660 − 0.038 (− 0.376 to − 0.008) 0.0412
Depressive symptom 0.068 (0.274–0.875) 0.0002 0.067 (0.268–0.867) 0.0002 0.067 (0.272–0.870) 0.0002 0.064 (0.241–0.843) 0.0004
hs-CRP 0.033 (− 0.055–0.749) 0.091 0.033 (− 0.050–0.743) 0.0864 0.030 (− 0.071–0.704) 0.1094 0.037 (0.003–0.781) 0.0484
Hb-A1c − 0.001 (− 0.367–0.350) 0.9628 − 0.001 (− 0.349–0.365) 0.9649
HDL-cholesterol 0.010 (− 0.009–0.015) 0.6405 0.015 (− 0.007–0.015) 0.4626
LDL-cholesterol − 0.018 (− 0.009–0.015) 0.3365
Triglyceride − 0.014 (− 0.005–0.003) 0.5066
Uric acid − 0.012 (− 0.212–0.119) 0.5814
  1. Reduced model 1: Selected the variable which showed a statistically significant correlation with JKOM pain. Reduced model 2: Selected the variable by stepwise method. Reduced model 3: Excluded age from reduced model 2
  2. Variables in bold indicate statistically significant results
  3. BMI body mass index, K/L Kellgren/Lawrence, BMD bone mineral density, hs-CRP high-sensitivity C-reactive protein, HbA1c hemoglobin A1c