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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Long non-coding RNA HOTAIR induces GLI2 expression through Notch signalling in systemic sclerosis dermal fibroblasts

Fig. 2

HOTAIR suppresses miRNA-34a to enhance Notch-mediated GLI2 expression. RNA was extracted from HOTAIR-expressing fibroblasts transfected with an miRNA-34a mimic or a scramble miRNA mimic. GLI2 (a), NOTCH1 (b) and miRNA-34a (c) transcript levels were analysed. Graphs represent the mean and standard error for three independent experiments. RNA was extracted from SSc fibroblasts transfected with miRNA-34a mimic or a scramble miRNA mimic. GLI2 (d), NOTCH1 (e) and miRNA34a (f) transcript levels were analysed. Graphs represent the mean and standard error for three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001

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Arthritis Research & Therapy

ISSN: 1478-6362

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