Table 2 Comparison of AMBITION cohort with healthy controls in patient demographics and baseline biomarker levels. Differences between cohorts are shown as ANCOVA values adjusted for race differences
Variables | AMBITION cohort RA patients (N = 387) | Healthy controls (N = 72) | Difference between cohorts |
|---|---|---|---|
Age (years), mean (SD) | 50.9 (12.9) | 49.7 (6.1) | ns |
Female, n (%) | 300 (76) | 41 (76) | ns |
Race, no. white/black/other (%) | 325 (84)/14 (4)/48 (12) | 51 (71)/21 (29)/0 (0) | < 0.0001 |
Baseline C1M (ng/mL), mean (SD) | 43.4 (30.7) | 18.7 (15.3) | < 0.001 |
Baseline C2M (ng/mL), mean (SD) | 0.38 (0.2) | 0.3 (0.16) | < 0.001 |
Baseline C3M (ng/mL), mean (SD) | 17.8 (8.0) | 11.1 (2.8) | < 0.001 |
Baseline C4M (ng/mL), mean (SD) | 50.9 (24.9) | 21.5 (6.1) | < 0.001 |
Baseline CRPM (ng/mL), mean (SD) | 20.9 (12.9) | 7.5 (2.1) | < 0.001 |
Baseline CRP (ng/mL), mean (SD) | 3.0 (3.5) | – |  |