Connective tissue remodelling is differently modulated by tocilizumab versus methotrexate monotherapy in patients with early rheumatoid arthritis: the AMBITION study

Table 4 Correlation between week 8 change in levels of respective biomarkers according to the treatment group and change in disease activity (ΔDAS28) at weeks 8, 16 and 24. Correlation values are given as Spearman’s correlation coefficient (rho) and significance as P value. Significant correlations with P < 0.0083 have been highlighted (Bonferroni correction)

Biomarker	Tocilizumab			Methotrexate
Biomarker	ΔDAS28 week 8	ΔDAS28 week 16	ΔDAS28 week 24	ΔDAS28 week 8	ΔDAS28 week 16	ΔDAS28week 24
C1M	rho = 0.08	rho = 0.06	rho = 0.002	rho = 0.11	rho = 0.06	rho = 0.08
C1M	P = 0.43	P = 0.53	P = 0.98	P = 0.22	P = 0.53	P = 0.4
C2M	rho = 0.02	rho = 0.03	rho = 0.02	rho = 0.04	rho = − 0.04	rho = 0.02
C2M	P = 0.87	P = 0.73	P = 0.83	P = 0.66	P = 0.69	P = 0.87
C3M	rho = 0.1	rho = 0.12	rho = 0.05	rho = 0.32	rho = 0.3	rho = 0.26
C3M	P = 0.24	P = 0.16	P = 0.54	P = 0.0001	P = 0.0005	P = 0.003
C4M	rho = 0.08	rho = 0.08	rho = − 0.01	rho = 0.35	rho = 0.32	rho = 0.26
C4M	P = 0.38	P = 0.37	P = 0.89	P < 0.0001	P = 0.0001	P = 0.002
CRP	rho = 0.32	rho = 0.31	rho = 0.21	rho = 0.41	rho = 0.34	rho = 0.25
CRP	P < 0.0001	P = 0.0001	P = 0.01	P < 0.0001	P < 0.0001	P = 0.0026
CRPM	rho = 0.13	rho = 0.13	rho = 0.1	rho = 0.29	rho = 0.18	rho = 0.21
CRPM	P = 0.13	P = 0.14	P = 0.24	P = 0.0006	P = 0.039	P = 0.016

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