Biomarker | Tocilizumab | Methotrexate | ||||
---|---|---|---|---|---|---|
ΔDAS28 week 8 | ΔDAS28 week 16 | ΔDAS28 week 24 | ΔDAS28 week 8 | ΔDAS28 week 16 | ΔDAS28week 24 | |
C1M | rho = 0.08 | rho = 0.06 | rho = 0.002 | rho = 0.11 | rho = 0.06 | rho = 0.08 |
P = 0.43 | P = 0.53 | P = 0.98 | P = 0.22 | P = 0.53 | P = 0.4 | |
C2M | rho = 0.02 | rho = 0.03 | rho = 0.02 | rho = 0.04 | rho = − 0.04 | rho = 0.02 |
P = 0.87 | P = 0.73 | P = 0.83 | P = 0.66 | P = 0.69 | P = 0.87 | |
C3M | rho = 0.1 | rho = 0.12 | rho = 0.05 | rho = 0.32 | rho = 0.3 | rho = 0.26 |
P = 0.24 | P = 0.16 | P = 0.54 | P = 0.0001 | P = 0.0005 | P = 0.003 | |
C4M | rho = 0.08 | rho = 0.08 | rho = − 0.01 | rho = 0.35 | rho = 0.32 | rho = 0.26 |
P = 0.38 | P = 0.37 | P = 0.89 | P < 0.0001 | P = 0.0001 | P = 0.002 | |
CRP | rho = 0.32 | rho = 0.31 | rho = 0.21 | rho = 0.41 | rho = 0.34 | rho = 0.25 |
P < 0.0001 | P = 0.0001 | P = 0.01 | P < 0.0001 | P < 0.0001 | P = 0.0026 | |
CRPM | rho = 0.13 | rho = 0.13 | rho = 0.1 | rho = 0.29 | rho = 0.18 | rho = 0.21 |
P = 0.13 | P = 0.14 | P = 0.24 | P = 0.0006 | P = 0.039 | P = 0.016 |