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Table 4 Correlation between week 8 change in levels of respective biomarkers according to the treatment group and change in disease activity (ΔDAS28) at weeks 8, 16 and 24. Correlation values are given as Spearman’s correlation coefficient (rho) and significance as P value. Significant correlations with P < 0.0083 have been highlighted (Bonferroni correction)

From: Connective tissue remodelling is differently modulated by tocilizumab versus methotrexate monotherapy in patients with early rheumatoid arthritis: the AMBITION study

Biomarker Tocilizumab Methotrexate
ΔDAS28 week 8 ΔDAS28 week 16 ΔDAS28 week 24 ΔDAS28 week 8 ΔDAS28 week 16 ΔDAS28week 24
C1M rho = 0.08 rho = 0.06 rho = 0.002 rho = 0.11 rho = 0.06 rho = 0.08
P = 0.43 P = 0.53 P = 0.98 P = 0.22 P = 0.53 P = 0.4
C2M rho = 0.02 rho = 0.03 rho = 0.02 rho = 0.04 rho = − 0.04 rho = 0.02
P = 0.87 P = 0.73 P = 0.83 P = 0.66 P = 0.69 P = 0.87
C3M rho = 0.1 rho = 0.12 rho = 0.05 rho = 0.32 rho = 0.3 rho = 0.26
P = 0.24 P = 0.16 P = 0.54 P = 0.0001 P = 0.0005 P = 0.003
C4M rho = 0.08 rho = 0.08 rho = − 0.01 rho = 0.35 rho = 0.32 rho = 0.26
P = 0.38 P = 0.37 P = 0.89 P < 0.0001 P = 0.0001 P = 0.002
CRP rho = 0.32 rho = 0.31 rho = 0.21 rho = 0.41 rho = 0.34 rho = 0.25
P < 0.0001 P = 0.0001 P = 0.01 P < 0.0001 P < 0.0001 P = 0.0026
CRPM rho = 0.13 rho = 0.13 rho = 0.1 rho = 0.29 rho = 0.18 rho = 0.21
P = 0.13 P = 0.14 P = 0.24 P = 0.0006 P = 0.039 P = 0.016