From: Long-term remission and biologic persistence rates: 12-year real-world data
 | Baseline | 1 Year Review | 12 Year Review | ||||||
---|---|---|---|---|---|---|---|---|---|
RA (n = 274) | PsA (n = 129) | p | RA (n = 203) | PsA (n = 96) | p | RA (n = 179) | PsA (n = 87) | p | |
Biologic | |||||||||
 Adalimumab | 144 (52.6%) | 47 (36.4%) | 0.002 | 76 (44.7%) | 27 (31.0%) | 0.034 | 43 (25.6%) | 28 (33.3%) | NS |
 Etanercept | 100 (36.5%) | 68 (52.7%) | 0.002 | 62 (36.5%) | 45 (51.7%) | 0.019 | 48 (28.6%) | 30 (35.7%) | NS |
 Infliximab | 18 (6.6%) | 14 (10.9%) | NS | 13 (7.6%) | 11 (12.6%) | NS | 3 (1.8%) | 8 (9.5%) | 0.004 |
 Rituximab | 12 (4.4%) | 0 | 0.011 | 4 (2.4%) | 0 | NS | 16 (9.5%) | 0 | 0.004 |
 Othera | 0 | 0 |  | 1 (0.6%) | 0 | NS | 24 (14.3%) | 8 (9.5%) | NS |
 None | 0 | 0 |  | 14 (5.1%) | 4 (3.1%) | NS | 34 (20.2%) | 10 (11.9%) | NS |
Biologic persistence | n/a | n/a | n/a | 136 (49.6%) | 76 (58.9%) | NS | 66 (38.2%) | 45 (52.3%) | NS |
Methotrexate | 176 (64.2%) | 35 (27.3%) | <0.001 | 108 (64.8%) | 21 (24.4%) | <0.001 | 72 (42.2%) | 22 (25.9%) | 0.008 |
PGH, mm | 60 (0-100) | 50 (0-100) | NS | 30 (0-100) | 20 (0-90) | <0.001 | 50 (0-100) | 5 (0-100) | <0.001 |
TJC28 | 9 (0-28) | 6 (0-28) | <0.001 | 1 (0-28) | 0 (0-20) | <0.001 | 0 (0-19) | 0 (0-2) | 0.019 |
SJC28 | 9 (0-28) | 5 (0-28) | <0.001 | 1 (0-28) | 0 (0-25) | <0.001 | 0 (0-15) | 0 (0-2) | <0.001 |
CRP, mg/L | 16 (2-158) | 9 (0-108) | <0.001 | 4 (1-138) | 4 (0-41) | 0.034 | 3 (1-65) | 2 (1-46) | <0.001 |
Disease Activity | |||||||||
 Low | 9 (3.5%) | 13 (11.1%) | 0.003 | 91 (55.2%) | 60 (82.2%) | <0.001 | 83 (79.8%) | 22 (95.7%) | NS |
 Moderate | 89 (34.4%) | 65 (55.6%) | <0.001 | 58 (35.2%) | 10 (13.7%) | 0.001 | 20 (19.2%) | 1 (4.3%) | 0.012 |
 High | 160 (61.8%) | 39 (33.3%) | <0.001 | 16 (9.7%) | 3 (4.1%) | NS | 1 (1%) | 0 (0%) | NS |
Erosion progression | 36 (28.1%) | 5 (8.6%) | 0.003 | 51 (31.9%) | 12 (15.0%) | 0.005 |