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Table 2 Histological grading scale for the defects of cartilage

From: Silk fibroin hydrogel scaffolds incorporated with chitosan nanoparticles repair articular cartilage defects by regulating TGF-β1 and BMP-2

Category Score
Cell morphology
 Hyaline cartilage 0
 Mostly hyaline cartilage 1
 Mostly fibrocartilage 2
 Mostly non-cartilage 3
 Non-cartilage only 4
Matrix staining
 Normal 0
 Slightly reduced 1
 Markedly reduced 2
 No metachromatic stain 3
Surface regularity*
 Smooth (> 3/4) 0
 Moderate (> 1/2–3/4) 1
 Irregular (1/4–1/2) 2
 Severely irregular (< 1/4) 3
Thickness of cartilage#
 > 2/3 0
 1/3–2/3 1
 < 1/3 2
Integration of donor with adjacent host cartilage
 Both edges integrated 0
 One edge integrated 1
 Neither edge integrated 2
 Total maximum 14
  1. *Total smooth area of the reparative cartilage compared with the entire area of the cartilage defect
  2. #Average thickness of the reparative cartilage compared with that of the surrounding cartilage