TY - JOUR AU - Cross, M. AU - Smith, E. AU - Hoy, D. AU - Carmona, L. AU - Wolfe, F. AU - Vos, T. AU - Williams, B. AU - Gabriel, S. AU - Lassere, M. AU - Johns, N. AU - Buchbinder, R. AU - Woolf, A. AU - March, L. PY - 2014 DA - 2014// TI - The global burden of rheumatoid arthritis: estimates from the global burden of disease 2010 study JO - Ann Rheum Dis VL - 73 UR - https://doi.org/10.1136/annrheumdis-2013-204627 DO - 10.1136/annrheumdis-2013-204627 ID - Cross2014 ER - TY - JOUR AU - Moreland, L. W. AU - Baumgartner, S. W. AU - Schiff, M. H. AU - Tindall, E. A. AU - Fleischmann, R. M. AU - Weaver, A. L. AU - Ettlinger, R. E. AU - Cohen, S. AU - Koopman, W. J. AU - Mohler, K. AU - Widmer, M. B. AU - Blosch, C. M. PY - 1997 DA - 1997// TI - Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein JO - N Engl J Med VL - 337 UR - https://doi.org/10.1056/NEJM199707173370301 DO - 10.1056/NEJM199707173370301 ID - Moreland1997 ER - TY - JOUR AU - Wijbrandts, C. A. AU - Tak, P. P. PY - 2017 DA - 2017// TI - Prediction of response to targeted treatment in rheumatoid arthritis JO - Mayo Clin Proc VL - 92 UR - https://doi.org/10.1016/j.mayocp.2017.05.009 DO - 10.1016/j.mayocp.2017.05.009 ID - Wijbrandts2017 ER - TY - JOUR AU - Frostegard, J. PY - 2011 DA - 2011// TI - Cardiovascular co-morbidity in patients with rheumatic diseases JO - Arthritis Res Ther VL - 13 UR - https://doi.org/10.1186/ar3326 DO - 10.1186/ar3326 ID - Frostegard2011 ER - TY - JOUR AU - Choy, E. AU - Ganeshalingam, K. AU - Semb, A. G. AU - Szekanecz, Z. AU - Nurmohamed, M. PY - 2014 DA - 2014// TI - Cardiovascular risk in rheumatoid arthritis: recent advances in the understanding of the pivotal role of inflammation, risk predictors and the impact of treatment JO - Rheumatology (Oxford) VL - 53 UR - https://doi.org/10.1093/rheumatology/keu224 DO - 10.1093/rheumatology/keu224 ID - Choy2014 ER - TY - STD TI - Karpouzas GA, Ormseth SR, Hernandez E and Budoff MJ. Biologics May Prevent C. ardiovascular Events in Rheumatoid Arthritis by Inhibiting Coronary Plaque Formation and Stabilizing High-Risk Lesions. Arthritis Rheumatol. 2020;72:1467–75. ID - ref6 ER - TY - JOUR AU - Cohen, J. C. AU - Boerwinkle, E. AU - Mosley, T. H. AU - Hobbs, H. H. PY - 2006 DA - 2006// TI - Sequence variations in PCSK9, low LDL, and protection against coronary heart disease JO - N Engl J Med VL - 354 UR - https://doi.org/10.1056/NEJMoa054013 DO - 10.1056/NEJMoa054013 ID - Cohen2006 ER - TY - JOUR AU - Kathiresan, S. PY - 2008 DA - 2008// TI - A PCSK9 missense variant associated with a reduced risk of early-onset myocardial infarction JO - N Engl J Med VL - 358 UR - https://doi.org/10.1056/NEJMc0707445 DO - 10.1056/NEJMc0707445 ID - Kathiresan2008 ER - TY - JOUR AU - Abifadel, M. AU - Varret, M. AU - Rabes, J. P. AU - Allard, D. AU - Ouguerram, K. AU - Devillers, M. AU - Cruaud, C. AU - Benjannet, S. AU - Wickham, L. AU - Erlich, D. AU - Derre, A. AU - Villeger, L. AU - Farnier, M. AU - Beucler, I. AU - Bruckert, E. AU - Chambaz, J. AU - Chanu, B. AU - Lecerf, J. M. AU - Luc, G. AU - Moulin, P. AU - Weissenbach, J. AU - Prat, A. AU - Krempf, M. AU - Junien, C. AU - Seidah, N. G. AU - Boileau, C. PY - 2003 DA - 2003// TI - Mutations in PCSK9 cause autosomal dominant hypercholesterolemia JO - Nat Genet VL - 34 UR - https://doi.org/10.1038/ng1161 DO - 10.1038/ng1161 ID - Abifadel2003 ER - TY - JOUR AU - Lagace, T. A. PY - 2014 DA - 2014// TI - PCSK9 and LDLR degradation: regulatory mechanisms in circulation and in cells JO - Curr Opin Lipidol VL - 25 UR - https://doi.org/10.1097/MOL.0000000000000114 DO - 10.1097/MOL.0000000000000114 ID - Lagace2014 ER - TY - JOUR AU - Bergeron, N. AU - Phan, B. A. AU - Ding, Y. AU - Fong, A. AU - Krauss, R. M. PY - 2015 DA - 2015// TI - Proprotein convertase subtilisin/kexin type 9 inhibition: a new therapeutic mechanism for reducing cardiovascular disease risk JO - Circulation. VL - 132 UR - https://doi.org/10.1161/CIRCULATIONAHA.115.016080 DO - 10.1161/CIRCULATIONAHA.115.016080 ID - Bergeron2015 ER - TY - JOUR AU - Seidah, N. G. AU - Abifadel, M. AU - Prost, S. AU - Boileau, C. AU - Prat, A. PY - 2017 DA - 2017// TI - The proprotein convertases in hypercholesterolemia and cardiovascular diseases: emphasis on proprotein convertase subtilisin/kexin 9 JO - Pharmacol Rev VL - 69 UR - https://doi.org/10.1124/pr.116.012989 DO - 10.1124/pr.116.012989 ID - Seidah2017 ER - TY - JOUR AU - Park, S. W. AU - Moon, Y. A. AU - Horton, J. D. PY - 2004 DA - 2004// TI - Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver JO - J Biol Chem VL - 279 UR - https://doi.org/10.1074/jbc.M410077200 DO - 10.1074/jbc.M410077200 ID - Park2004 ER - TY - STD TI - Frostegard J, Zhang Y, Sun J, Yan K and Liu A. Oxidized Low-Density Lipoprotein (OxLDL)-Treated Dendritic Cells Promote Activation of T Cells in Human Atherosclerotic Plaque and Blood, Which Is Repressed by Statins: microRNA let-7c Is Integral to the Effect. J Am Heart Assoc. 2016;5:e003976. ID - ref14 ER - TY - STD TI - Liu A, Frostegard J. PCSK9 plays a novel immunological role in oxidized LDL-induced dendritic cell maturation and activation of T cells from human blood and atherosclerotic plaque. J Intern Med. 2018;284:193–210. ID - ref15 ER - TY - JOUR AU - Frostegard, J. PY - 2013 DA - 2013// TI - Immunity, atherosclerosis and cardiovascular disease JO - BMC Med VL - 11 UR - https://doi.org/10.1186/1741-7015-11-117 DO - 10.1186/1741-7015-11-117 ID - Frostegard2013 ER - TY - STD TI - Liu A, Rahman M, Hafstrom I, Ajeganova S and Frostegard J. Proprotein convertase subtilisin kexin 9 is associated with disease activity and is implicated in immune activation in systemic lupus erythematosus. Lupus. 2020;29(8):825–35. ID - ref17 ER - TY - JOUR AU - Ricci, C. AU - Ruscica, M. AU - Camera, M. AU - Rossetti, L. AU - Macchi, C. AU - Colciago, A. AU - Zanotti, I. AU - Lupo, M. G. AU - Adorni, M. P. AU - Cicero, A. F. G. AU - Fogacci, F. AU - Corsini, A. AU - Ferri, N. PY - 2018 DA - 2018// TI - PCSK9 induces a pro-inflammatory response in macrophages JO - Sci Rep VL - 8 UR - https://doi.org/10.1038/s41598-018-20425-x DO - 10.1038/s41598-018-20425-x ID - Ricci2018 ER - TY - JOUR AU - Fransen, J. AU - Creemers, M. C. AU - Riel, P. L. PY - 2004 DA - 2004// TI - Remission in rheumatoid arthritis: agreement of the disease activity score (DAS28) with the ARA preliminary remission criteria JO - Rheumatology (Oxford) VL - 43 UR - https://doi.org/10.1093/rheumatology/keh297 DO - 10.1093/rheumatology/keh297 ID - Fransen2004 ER - TY - JOUR AU - Ekdahl, C. AU - Eberhardt, K. AU - Andersson, S. I. AU - Svensson, B. PY - 1988 DA - 1988// TI - Assessing disability in patients with rheumatoid arthritis. Use of a Swedish version of the Stanford Health Assessment Questionnaire JO - Scand J Rheumatol VL - 17 UR - https://doi.org/10.3109/03009748809098795 DO - 10.3109/03009748809098795 ID - Ekdahl1988 ER - TY - JOUR AU - Leander, K. AU - Malarstig, A. AU - Hooft, F. M. AU - Hyde, C. AU - Hellenius, M. L. AU - Troutt, J. S. AU - Konrad, R. J. AU - Ohrvik, J. AU - Hamsten, A. AU - Faire, U. PY - 2016 DA - 2016// TI - Circulating proprotein convertase subtilisin/kexin type 9 (PCSK9) predicts future risk of cardiovascular events independently of established risk factors JO - Circulation. VL - 133 UR - https://doi.org/10.1161/CIRCULATIONAHA.115.018531 DO - 10.1161/CIRCULATIONAHA.115.018531 ID - Leander2016 ER - TY - JOUR AU - Vollenhoven, R. F. AU - Nagy, G. AU - Tak, P. P. PY - 2014 DA - 2014// TI - Early start and stop of biologics: has the time come? JO - BMC Med VL - 12 UR - https://doi.org/10.1186/1741-7015-12-25 DO - 10.1186/1741-7015-12-25 ID - Vollenhoven2014 ER - TY - JOUR AU - Alam, J. AU - Jantan, I. AU - Bukhari, S. N. A. PY - 2017 DA - 2017// TI - Rheumatoid arthritis: recent advances on its etiology, role of cytokines and pharmacotherapy JO - Biomed Pharmacother VL - 92 UR - https://doi.org/10.1016/j.biopha.2017.05.055 DO - 10.1016/j.biopha.2017.05.055 ID - Alam2017 ER - TY - JOUR AU - Udalova, I. A. AU - Mantovani, A. AU - Feldmann, M. PY - 2016 DA - 2016// TI - Macrophage heterogeneity in the context of rheumatoid arthritis JO - Nat Rev Rheumatol VL - 12 UR - https://doi.org/10.1038/nrrheum.2016.91 DO - 10.1038/nrrheum.2016.91 ID - Udalova2016 ER - TY - JOUR AU - Koch, A. E. AU - Kunkel, S. L. AU - Harlow, L. A. AU - Johnson, B. AU - Evanoff, H. L. AU - Haines, G. K. AU - Burdick, M. D. AU - Pope, R. M. AU - Strieter, R. M. PY - 1992 DA - 1992// TI - Enhanced production of monocyte chemoattractant protein-1 in rheumatoid arthritis JO - J Clin Invest VL - 90 UR - https://doi.org/10.1172/JCI115950 DO - 10.1172/JCI115950 ID - Koch1992 ER - TY - JOUR AU - Shahrara, S. AU - Proudfoot, A. E. AU - Park, C. C. AU - Volin, M. V. AU - Haines, G. K. AU - Woods, J. M. AU - Aikens, C. H. AU - Handel, T. M. AU - Pope, R. M. PY - 2008 DA - 2008// TI - Inhibition of monocyte chemoattractant protein-1 ameliorates rat adjuvant-induced arthritis JO - J Immunol (Baltimore) VL - 180 ID - Shahrara2008 ER - TY - STD TI - Frostegard J, Wu R, Giscombe R, Holm G, Lefvert AK and Nilsson J. Induction of T-cell activation by oxidized low density lipoprotein. Arterioscler Thromb. 1992;12:461–7. ID - ref27 ER - TY - STD TI - Frostegard J, Nilsson J, Haegerstrand A, Hamsten A, Wigzell H and Gidlund M. Oxidized low density lipoprotein induces differentiation and adhesion of human monocytes and the monocytic cell line U937. Proc Natl Acad Sci U S A. 1990;87:904–8. ID - ref28 ER - TY - STD TI - Liu A, Ming JY, Fiskesund R, Ninio E, Karabina SA, Bergmark C, Frostegard AG and Frostegard J. Induction of dendritic cell-mediated T-cell activation by modified but not native low-density lipoprotein in humans and inhibition by annexin a5: involvement of heat shock proteins. Arterioscler Thromb Vasc Biol. 2015;35:197–205. ID - ref29 ER - TY - STD TI - Winyard PG, Tatzber F, Esterbauer H, Kus ML, Blake DR and Morris CJ. Presence of foam cells containing oxidised low density lipoprotein in the synovial membrane from patients with rheumatoid arthritis. Ann Rheum Dis. 1993;52:677–80. ID - ref30 ER - TY - STD TI - Nowak B, Madej M, Luczak A, Malecki R and Wiland P. Disease Activity, Oxidized-LDL Fraction and Anti-Oxidized LDL Antibodies Influence Cardiovascular Risk in Rheumatoid Arthritis. Adv Clin Exp Med. 2016;25:43–50. ID - ref31 ER - TY - STD TI - Scheinecker C, Goschl L and Bonelli M. Treg cells in health and autoimmune diseases: New insights from single cell analysis. J Autoimmun. 2020;110:102376. ID - ref32 ER -