Lab parameter† n (%) | Upadacitinib 7.5 mg QD (n = 65) | Upadacitinib 15 mg QD (n = 64) | Upadacitinib 30 mg QD (n = 66) |
---|---|---|---|
Hemoglobin (g/L) | |||
Grade 3 (70 to < 80 or ↓ 21 to < 30) | 0 | 1 (1.6) | 9 (13.6) |
Grade 4 (< 70 or ↓ ≥ 30) | 1 (1.5) | 0 | 4 (6.1) |
Lymphocytes (× 109/L) | |||
Grade 3 (0.5 to < 1.0) | 30 (46.2) | 27 (42.2) | 36 (54.5) |
Grade 4 (< 0.5) | 4 (6.2) | 2 (3.1) | 4 (6.1) |
Neutrophils (× 109/L) | |||
Grade 3 (0.5 to < 1.0) | 1 (1.5) | 1 (1.6) | 2 (3.0) |
Grade 4 (< 0.5) | 1 (1.5) | 0 | 0 |
Leukocytes (× 109/L) | |||
Grade 3 (1.0 to < 2.0) | 1 (1.5) | 0 | 1 (1.5) |
Grade 4 (< 1.0) | 0 | 0 | 0 |
ALT (U/L) | |||
Grade 3 (3.0–8.0 × ULN) | 1 (1.5) | 3 (4.7) | 2 (3.0) |
Grade 4 (> 8.0 × ULN) | 0 | 0 | 1 (1.5) |
AST (U/L) | |||
Grade 3 (3.0–8.0 × ULN) | 1 (1.5) | 2 (3.1) | 2 (3.0) |
Grade 4 (> 8.0 × ULN) | 0 | 0 | 0 |
CPK (U/L) | |||
Grade 3 (> 5–10 × ULN) | 2 (3.1) | 2 (3.1) | 3 (4.5) |
Grade 4 (> 10 × ULN) | 0 | 1 (1.6) | 4 (6.1) |
Creatinine (μmol/L) | |||
Grade 3 (> 3.0–6.0 × ULN) | 0 | 0 | 0 |
Grade 4 (> 6.0 × ULN) | 0 | 0 | 0 |