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Table 1 Clinical and laboratory features of enrolled individuals

From: Expansion of circulating peripheral TIGIT+CD226+ CD4 T cells with enhanced effector functions in dermatomyositis

 

DM

HCs

Number

30

26

Age (years)

45.3 ± 12.5

44.8 ± 10.7

Sex (male to female)

10:16

10/16

Disease duration (months)

3 (1–48)

NA

Major clinical features

 Skin rash (%)

100% (30/30)

NA

 Muscular weakness (%)

60% (18/30)

NA

 Arthralgia (%)

37% (11/30)

NA

 Dysphagia (%)

20% (6/30)

NA

 ILD (%)

53% (16/30)

NA

 Malignancy (%)

3% (1/30)

NA

 MYOACT score (mean ± SD)

0.213 ± 0.072

NA

Major laboratory features

 CK (IU/L), median (IQR)

326 (130–4852)

NA

 LDH (IU/L), median (IQR)

262 (40–2953)

NA

 MSA positive (%)

80% (24/30)

NA

 Anti-MDA5+ (%)

38% (9/24)

NA

 Anti-TIF1-r+ (%)

25% (6/24)

NA

 Anti-NXP2+ (%)

8% (2/24)

NA

 Anti-Mi-2+ (%)

8% (2/24)

NA

 Anti-PL-7+ (%)

13% (3/24)

NA

 Anti-EJ+ (%)

8% (2/24)

NA

 CD4 T cells (cells/μl)

421 (287–1377)

NA

 CD8 T cells (cells/μl)

209 (60–681)

NA

  1. ILD interstitial lung disease, ANA antinuclear antibodies, CK creatine kinas, IQR interquartile range, LDH lactate dehydrogenase, MSA myositis-specific antibodies, NA not applicable