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Table 2 Distribution of genotypes and allele frequencies of miRNA SNPs among patients with MCTD and healthy subjects (p = MCTD vs controls)

From: Association study between immune-related miRNAs and mixed connective tissue disease

SNP Genotype MCTD
n (%)
Controls
n (%)
Adjusted OR
(95% CI)
p value
miR-155 rs1893650 C/T
 Codominant CC 79 (56.43) 333 (62.95)
CT 57 (40.71) 173 (32.70) 1.42 (0.89–2.27) 0.1
TT 4 (2.86) 23 (4.35) 0.82 (0.19–2.62) 0.8
 Dominant CC 79 (56.43) 333 (62.95)
TT+CT 61 (43.57) 196 (37.05) 1.35 (0.86–2.13) 0.2
 Recessive CC+CT 136 (97.14) 506 (95.65)
TT 4 (2.86) 23 (4.35) 0.73 (0.16–2.25) 0.6
 Overdominant TT+CC 83 (59.29) 356 (67.30)
CT 57 (40.71) 173 (32.70) 1.44 (0.90–2.27) 0.1
 Alleles C 215 (76.79) 839 (79.3)
T 65 (23.21) 219 (20.7) 1.16 (1.59–0.85) 0.36
miR-155 rs2829806 G/T
 Codominant GG 71 (59.66) 285 (61.69)  
GT 44 (36.9) 153 (33.12) 1.29 (0.77–2.13) 0.3
TT 4 (3.3) 24 (5.19) 0.63 (0.13–2.12) 0.5
 Dominant GG 71 (59.6) 285 (61.69)
TT+GT 48 (40.4) 177 (38.31) 1.2 (0.73–1.95) 0.4
 Recessive CC+GT 115 (96.6) 438 (94.8)
TT 4 (3.36) 24 (5.19) 0.58 (0.12–1.89) 0.4
 Overdominant TT+GG 75 (63.03) 309 (66.88)
GT 44 (36.97) 153 (33.12) 1.33 (0.80–2.17) 0.2
 Alleles T 52 (21.85) 201 (21.75)
G 186 (78.15) 723 (78.25) 1 (1.42–0.71) 0.9
miR-146a rs29101164 G/C
 Codominant GG 69 (55.65) 316 (64.89)
GC 51 (41.12) 153 (31.42) 1.47 (0.74–8.68) 0.1
CC 4 (3.23) 18 (3.7) 2.80 (0.89–2.41) 0.09
 Dominant GG 69 (55.65) 316 (64.89)
CC+GC 55 (44.35) 171 (35.11) 1.55 (0.96–2.51) 0.07
 Recessive GG+GC 120 (96.77) 469 (96.30)
CC 4 (3.23) 18 (3.7) 2.43 (0.65–7.36) 0.1
 Overdominant CC+GG 73 (58.87) 334 (68.58)
GC 51 (41.12) 153 (31.42) 1.40 (0.85–2.26) 0.2
 Alleles C 59 (24.58) 189 (19.40)
G 181 (75.42) 785 (80.60) 1.35 (1.89–0.97) 0.08
miR-143 rs353291 T/C
 Codominant TT 47 (39.50) 140 (36.46)
TC 51 (42.86) 184 (47.92) 0.95 (0.55–1.66) 0.8
CC 21 (17.65) 60 (15.63) 1.17 (0.57–2.35) 0.6
 Dominant TT 47 (39.50) 140 (36.46)
CC +CT 72 (60.5) 244 (63.54) 1.01 (0.60–1.70) 0.9
 Recessive TT+CT 98 (82.35) 324 (84.37)
CC 21 (17.65) 60 (15.63) 1.2 (0.62–2.24) 0.5
 Overdominant TT+CC 68 (57.14) 200 (52.08)
TC 51 (42.86) 184 (47.92) 0.91 (0.55–1.48) 0.7
 Alleles T 145 (60.92) 464 (60.42)
C 93 (39.08) 304 (39.58) 0.97 (1.32–0.73) 0.9
miR-143 rs713147 T/A
 Codominant TT 63 (54.31) 148 (44.31)
TA 44 (37.93) 148 (44.31) 0.72 (0.41–1.23) 0.2
AA 9 (7.76) 38 (11.38) 0.52 (0.19–1.27) 0.1
 Dominant TT 63 (54.31) 148 (44.31)
AA +TA 53 (45.69) 186 (55.69) 0.68 (0.40–1.12) 0.1
 Recessive TT+TA 107 (92.24) 276 (88.62)
AA 9 (7.76) 38 (11.38) 0.61 (0.23–1.42) 0.2
 Overdominant TT+AA 72 (62.07) 186 (55.69)
TA 44 (37.93) 148 (44.31) 0.80 (0.47–1.34) 0.4
 Alleles T 170 (73.28) 444 (66.47)
A 62 (26.72) 224 (33.53) 0.72 (1–0.52) 0.06
miR-143 rs353298 A/G
 Codominant AA 47 (39.17) 179 (37.61)
AG 53 (44.17) 233 (48.95) 0.95 (0.56–1.61) 0.8
GG 20 (16.17) 64 (13.45) 1.32 (0.64–2.62) 0.4
 Dominant AA 47 (39.17) 179 (37.61)
GG +AG 73 (60.83) 297 (62.39) 1.03 (0.63–1.70) 0.8
 Recessive AA+AG 100 (83.33) 412 (86.55)
GG 20 (16.17) 64 (13.45) 1.36 (0.70–2.51) 0.3
 Overdominant AA+GG 67 (55.83) 243 (51.05)
AG 53 (44.17) 233 (48.95) 0.87 (0.53–1.40) 0.5
 Alleles A 147 (61.25) 591 (62.08)
G 93 (38.75) 361 (37.92) 1.04 (1.39–0.77) 0.81
miR-143 rs353299 C/T
 Codominant CC 47 (38.52) 130 (38.92)
TC 56 (45.90) 162 (48.50) 1.13 (0.64–1.98) 0.6
TT 19 (15.57) 42 (12.57) 1.35 (0.61–2.93) 0.4
 Dominant CC 47 (38.52) 130 (38.92)
TT+CT 75 (38.52) 204 (38.92) 1.18 (0.69–2.01) 0.5
 Recessive CC+CT 103 (84.43) 292 (87.43)
TT 19 (15.57) 42 (12.57) 1.27 (0.60–2.54) 0.5
 Overdominant TT+CC 66 (54.1) 172 (51.5)
TC 56 (45.90) 162 (48.50) 1.04 (0.62–1.72) 0.8
 Alleles C 150 (61.48) 422 (63.17)
T 94 (38.52) 246 (36.83) 1.08 (1.45–0.79) 0.64
  1. MCTD mixed connective tissue diseases, n number of observations, OR odds ratio, CI confidence interval; p value obtained from linear regression, adjusted for gender and age; p value ≤ 0.05 was considered significant