From: Association study between immune-related miRNAs and mixed connective tissue disease
SNP | Genotype | MCTD n (%) | Controls n (%) | Adjusted OR (95% CI) | p value |
---|---|---|---|---|---|
miR-155 rs1893650 C/T | |||||
Codominant | CC | 79 (56.43) | 333 (62.95) | – | – |
CT | 57 (40.71) | 173 (32.70) | 1.42 (0.89–2.27) | 0.1 | |
TT | 4 (2.86) | 23 (4.35) | 0.82 (0.19–2.62) | 0.8 | |
Dominant | CC | 79 (56.43) | 333 (62.95) | – | – |
TT+CT | 61 (43.57) | 196 (37.05) | 1.35 (0.86–2.13) | 0.2 | |
Recessive | CC+CT | 136 (97.14) | 506 (95.65) | – | – |
TT | 4 (2.86) | 23 (4.35) | 0.73 (0.16–2.25) | 0.6 | |
Overdominant | TT+CC | 83 (59.29) | 356 (67.30) | – | – |
CT | 57 (40.71) | 173 (32.70) | 1.44 (0.90–2.27) | 0.1 | |
Alleles | C | 215 (76.79) | 839 (79.3) | – | – |
T | 65 (23.21) | 219 (20.7) | 1.16 (1.59–0.85) | 0.36 | |
miR-155 rs2829806 G/T | |||||
Codominant | GG | 71 (59.66) | 285 (61.69) | – | |
GT | 44 (36.9) | 153 (33.12) | 1.29 (0.77–2.13) | 0.3 | |
TT | 4 (3.3) | 24 (5.19) | 0.63 (0.13–2.12) | 0.5 | |
Dominant | GG | 71 (59.6) | 285 (61.69) | – | – |
TT+GT | 48 (40.4) | 177 (38.31) | 1.2 (0.73–1.95) | 0.4 | |
Recessive | CC+GT | 115 (96.6) | 438 (94.8) | – | – |
TT | 4 (3.36) | 24 (5.19) | 0.58 (0.12–1.89) | 0.4 | |
Overdominant | TT+GG | 75 (63.03) | 309 (66.88) | – | – |
GT | 44 (36.97) | 153 (33.12) | 1.33 (0.80–2.17) | 0.2 | |
Alleles | T | 52 (21.85) | 201 (21.75) | – | – |
G | 186 (78.15) | 723 (78.25) | 1 (1.42–0.71) | 0.9 | |
miR-146a rs29101164 G/C | |||||
Codominant | GG | 69 (55.65) | 316 (64.89) | – | – |
GC | 51 (41.12) | 153 (31.42) | 1.47 (0.74–8.68) | 0.1 | |
CC | 4 (3.23) | 18 (3.7) | 2.80 (0.89–2.41) | 0.09 | |
Dominant | GG | 69 (55.65) | 316 (64.89) | – | – |
CC+GC | 55 (44.35) | 171 (35.11) | 1.55 (0.96–2.51) | 0.07 | |
Recessive | GG+GC | 120 (96.77) | 469 (96.30) | – | – |
CC | 4 (3.23) | 18 (3.7) | 2.43 (0.65–7.36) | 0.1 | |
Overdominant | CC+GG | 73 (58.87) | 334 (68.58) | – | – |
GC | 51 (41.12) | 153 (31.42) | 1.40 (0.85–2.26) | 0.2 | |
Alleles | C | 59 (24.58) | 189 (19.40) | – | – |
G | 181 (75.42) | 785 (80.60) | 1.35 (1.89–0.97) | 0.08 | |
miR-143 rs353291 T/C | |||||
Codominant | TT | 47 (39.50) | 140 (36.46) | – | – |
TC | 51 (42.86) | 184 (47.92) | 0.95 (0.55–1.66) | 0.8 | |
CC | 21 (17.65) | 60 (15.63) | 1.17 (0.57–2.35) | 0.6 | |
Dominant | TT | 47 (39.50) | 140 (36.46) | – | – |
CC +CT | 72 (60.5) | 244 (63.54) | 1.01 (0.60–1.70) | 0.9 | |
Recessive | TT+CT | 98 (82.35) | 324 (84.37) | – | – |
CC | 21 (17.65) | 60 (15.63) | 1.2 (0.62–2.24) | 0.5 | |
Overdominant | TT+CC | 68 (57.14) | 200 (52.08) | – | – |
TC | 51 (42.86) | 184 (47.92) | 0.91 (0.55–1.48) | 0.7 | |
Alleles | T | 145 (60.92) | 464 (60.42) | – | – |
C | 93 (39.08) | 304 (39.58) | 0.97 (1.32–0.73) | 0.9 | |
miR-143 rs713147 T/A | |||||
Codominant | TT | 63 (54.31) | 148 (44.31) | – | – |
TA | 44 (37.93) | 148 (44.31) | 0.72 (0.41–1.23) | 0.2 | |
AA | 9 (7.76) | 38 (11.38) | 0.52 (0.19–1.27) | 0.1 | |
Dominant | TT | 63 (54.31) | 148 (44.31) | – | – |
AA +TA | 53 (45.69) | 186 (55.69) | 0.68 (0.40–1.12) | 0.1 | |
Recessive | TT+TA | 107 (92.24) | 276 (88.62) | – | – |
AA | 9 (7.76) | 38 (11.38) | 0.61 (0.23–1.42) | 0.2 | |
Overdominant | TT+AA | 72 (62.07) | 186 (55.69) | – | – |
TA | 44 (37.93) | 148 (44.31) | 0.80 (0.47–1.34) | 0.4 | |
Alleles | T | 170 (73.28) | 444 (66.47) | – | – |
A | 62 (26.72) | 224 (33.53) | 0.72 (1–0.52) | 0.06 | |
miR-143 rs353298 A/G | |||||
Codominant | AA | 47 (39.17) | 179 (37.61) | – | – |
AG | 53 (44.17) | 233 (48.95) | 0.95 (0.56–1.61) | 0.8 | |
GG | 20 (16.17) | 64 (13.45) | 1.32 (0.64–2.62) | 0.4 | |
Dominant | AA | 47 (39.17) | 179 (37.61) | – | – |
GG +AG | 73 (60.83) | 297 (62.39) | 1.03 (0.63–1.70) | 0.8 | |
Recessive | AA+AG | 100 (83.33) | 412 (86.55) | – | – |
GG | 20 (16.17) | 64 (13.45) | 1.36 (0.70–2.51) | 0.3 | |
Overdominant | AA+GG | 67 (55.83) | 243 (51.05) | – | – |
AG | 53 (44.17) | 233 (48.95) | 0.87 (0.53–1.40) | 0.5 | |
Alleles | A | 147 (61.25) | 591 (62.08) | – | – |
G | 93 (38.75) | 361 (37.92) | 1.04 (1.39–0.77) | 0.81 | |
miR-143 rs353299 C/T | |||||
Codominant | CC | 47 (38.52) | 130 (38.92) | – | – |
TC | 56 (45.90) | 162 (48.50) | 1.13 (0.64–1.98) | 0.6 | |
TT | 19 (15.57) | 42 (12.57) | 1.35 (0.61–2.93) | 0.4 | |
Dominant | CC | 47 (38.52) | 130 (38.92) | – | – |
TT+CT | 75 (38.52) | 204 (38.92) | 1.18 (0.69–2.01) | 0.5 | |
Recessive | CC+CT | 103 (84.43) | 292 (87.43) | – | – |
TT | 19 (15.57) | 42 (12.57) | 1.27 (0.60–2.54) | 0.5 | |
Overdominant | TT+CC | 66 (54.1) | 172 (51.5) | – | – |
TC | 56 (45.90) | 162 (48.50) | 1.04 (0.62–1.72) | 0.8 | |
Alleles | C | 150 (61.48) | 422 (63.17) | – | – |
T | 94 (38.52) | 246 (36.83) | 1.08 (1.45–0.79) | 0.64 |