Skip to main content

Table 2 Distribution of genotypes and allele frequencies of miRNA SNPs among patients with MCTD and healthy subjects (p = MCTD vs controls)

From: Association study between immune-related miRNAs and mixed connective tissue disease

SNP

Genotype

MCTD

n (%)

Controls

n (%)

Adjusted OR

(95% CI)

p value

miR-155 rs1893650 C/T

 Codominant

CC

79 (56.43)

333 (62.95)

CT

57 (40.71)

173 (32.70)

1.42 (0.89–2.27)

0.1

TT

4 (2.86)

23 (4.35)

0.82 (0.19–2.62)

0.8

 Dominant

CC

79 (56.43)

333 (62.95)

TT+CT

61 (43.57)

196 (37.05)

1.35 (0.86–2.13)

0.2

 Recessive

CC+CT

136 (97.14)

506 (95.65)

TT

4 (2.86)

23 (4.35)

0.73 (0.16–2.25)

0.6

 Overdominant

TT+CC

83 (59.29)

356 (67.30)

CT

57 (40.71)

173 (32.70)

1.44 (0.90–2.27)

0.1

 Alleles

C

215 (76.79)

839 (79.3)

T

65 (23.21)

219 (20.7)

1.16 (1.59–0.85)

0.36

miR-155 rs2829806 G/T

 Codominant

GG

71 (59.66)

285 (61.69)

 

GT

44 (36.9)

153 (33.12)

1.29 (0.77–2.13)

0.3

TT

4 (3.3)

24 (5.19)

0.63 (0.13–2.12)

0.5

 Dominant

GG

71 (59.6)

285 (61.69)

TT+GT

48 (40.4)

177 (38.31)

1.2 (0.73–1.95)

0.4

 Recessive

CC+GT

115 (96.6)

438 (94.8)

TT

4 (3.36)

24 (5.19)

0.58 (0.12–1.89)

0.4

 Overdominant

TT+GG

75 (63.03)

309 (66.88)

GT

44 (36.97)

153 (33.12)

1.33 (0.80–2.17)

0.2

 Alleles

T

52 (21.85)

201 (21.75)

G

186 (78.15)

723 (78.25)

1 (1.42–0.71)

0.9

miR-146a rs29101164 G/C

 Codominant

GG

69 (55.65)

316 (64.89)

GC

51 (41.12)

153 (31.42)

1.47 (0.74–8.68)

0.1

CC

4 (3.23)

18 (3.7)

2.80 (0.89–2.41)

0.09

 Dominant

GG

69 (55.65)

316 (64.89)

CC+GC

55 (44.35)

171 (35.11)

1.55 (0.96–2.51)

0.07

 Recessive

GG+GC

120 (96.77)

469 (96.30)

CC

4 (3.23)

18 (3.7)

2.43 (0.65–7.36)

0.1

 Overdominant

CC+GG

73 (58.87)

334 (68.58)

GC

51 (41.12)

153 (31.42)

1.40 (0.85–2.26)

0.2

 Alleles

C

59 (24.58)

189 (19.40)

G

181 (75.42)

785 (80.60)

1.35 (1.89–0.97)

0.08

miR-143 rs353291 T/C

 Codominant

TT

47 (39.50)

140 (36.46)

TC

51 (42.86)

184 (47.92)

0.95 (0.55–1.66)

0.8

CC

21 (17.65)

60 (15.63)

1.17 (0.57–2.35)

0.6

 Dominant

TT

47 (39.50)

140 (36.46)

CC +CT

72 (60.5)

244 (63.54)

1.01 (0.60–1.70)

0.9

 Recessive

TT+CT

98 (82.35)

324 (84.37)

CC

21 (17.65)

60 (15.63)

1.2 (0.62–2.24)

0.5

 Overdominant

TT+CC

68 (57.14)

200 (52.08)

TC

51 (42.86)

184 (47.92)

0.91 (0.55–1.48)

0.7

 Alleles

T

145 (60.92)

464 (60.42)

C

93 (39.08)

304 (39.58)

0.97 (1.32–0.73)

0.9

miR-143 rs713147 T/A

 Codominant

TT

63 (54.31)

148 (44.31)

TA

44 (37.93)

148 (44.31)

0.72 (0.41–1.23)

0.2

AA

9 (7.76)

38 (11.38)

0.52 (0.19–1.27)

0.1

 Dominant

TT

63 (54.31)

148 (44.31)

AA +TA

53 (45.69)

186 (55.69)

0.68 (0.40–1.12)

0.1

 Recessive

TT+TA

107 (92.24)

276 (88.62)

AA

9 (7.76)

38 (11.38)

0.61 (0.23–1.42)

0.2

 Overdominant

TT+AA

72 (62.07)

186 (55.69)

TA

44 (37.93)

148 (44.31)

0.80 (0.47–1.34)

0.4

 Alleles

T

170 (73.28)

444 (66.47)

A

62 (26.72)

224 (33.53)

0.72 (1–0.52)

0.06

miR-143 rs353298 A/G

 Codominant

AA

47 (39.17)

179 (37.61)

AG

53 (44.17)

233 (48.95)

0.95 (0.56–1.61)

0.8

GG

20 (16.17)

64 (13.45)

1.32 (0.64–2.62)

0.4

 Dominant

AA

47 (39.17)

179 (37.61)

GG +AG

73 (60.83)

297 (62.39)

1.03 (0.63–1.70)

0.8

 Recessive

AA+AG

100 (83.33)

412 (86.55)

GG

20 (16.17)

64 (13.45)

1.36 (0.70–2.51)

0.3

 Overdominant

AA+GG

67 (55.83)

243 (51.05)

AG

53 (44.17)

233 (48.95)

0.87 (0.53–1.40)

0.5

 Alleles

A

147 (61.25)

591 (62.08)

G

93 (38.75)

361 (37.92)

1.04 (1.39–0.77)

0.81

miR-143 rs353299 C/T

 Codominant

CC

47 (38.52)

130 (38.92)

TC

56 (45.90)

162 (48.50)

1.13 (0.64–1.98)

0.6

TT

19 (15.57)

42 (12.57)

1.35 (0.61–2.93)

0.4

 Dominant

CC

47 (38.52)

130 (38.92)

TT+CT

75 (38.52)

204 (38.92)

1.18 (0.69–2.01)

0.5

 Recessive

CC+CT

103 (84.43)

292 (87.43)

TT

19 (15.57)

42 (12.57)

1.27 (0.60–2.54)

0.5

 Overdominant

TT+CC

66 (54.1)

172 (51.5)

TC

56 (45.90)

162 (48.50)

1.04 (0.62–1.72)

0.8

 Alleles

C

150 (61.48)

422 (63.17)

T

94 (38.52)

246 (36.83)

1.08 (1.45–0.79)

0.64

  1. MCTD mixed connective tissue diseases, n number of observations, OR odds ratio, CI confidence interval; p value obtained from linear regression, adjusted for gender and age; p value ≤ 0.05 was considered significant