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Table 4 MCTD clinical parameters significantly associated with miR-146a rs2910164 G/C

From: Association study between immune-related miRNAs and mixed connective tissue disease

Scleroderma
miR-146a rs2910164 G/C n (%) Model p OR (95% CI) 95% CI
  Genotype GG GC CC CC + GC vs GG 0.14 2.06 (0.88–4.8)   
   Scleroderma 15 (27.78) 15 (38) 4 (100) GG + GC vs CC 0.01 18.74 0.9773 359.2678
   Without scleroderma 39 (72.22) 24 (62) 0 (0) CC + GG vs GC 0.72 1.28 0.55 2.99
  Allele G C   CC vs GG 0.04 22.94 1.1646 451.6701
   Scleroderma 45 (31) 23 (49)   GC vs GG 0.27 1.63 0.68 3.91
   Without scleroderma 102 (69) 24 (51)   C vs G 0.02 2.17 1.11 4.25
Lymphadenopathy
miR-146a rs2910164 G/C n (%) Model p OR 95% CI
  Genotype GG GC CC CC + GC vs GG 0.005 0.21 0.07 0.61
   Lymphadenopathy 21 (38.89) 5 (13) 0 (0) GG + GC vs CC 0.57 0.283 0.0147 5.4407
   Without lymphadenopathy 33 (61.11) 34 (87) 4 (100) CC + GG vs GC 0.01 0.26 0.09 0.76
  Allele G C   CC vs GG 0.24 0.1731 0.0089 3.3799
   Lymphadenopathy 47 (32) 5 (11)   GC vs GG 0.008 0.23 0.08 0.68
   Without lymphadenopathy 100 (68) 42 (89)   C vs G 0.006 0.25 0.09 0.68
  1. n number of patients with clinical manifestation; p< 0.05 is considered significant, indicated in bold; p value obtained from χ2 or Fisher exact test